Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis

  • Guillaume FondEmail author
  • Anderson Loundou
  • Nora Hamdani
  • Wahid Boukouaci
  • Aroldo Dargel
  • José Oliveira
  • Matthieu Roger
  • Ryad Tamouza
  • Marion Leboyer
  • Laurent Boyer
Original Paper


Irritable bowel syndrome (IBS) has been associated with high prevalence of psychological disorders. However, it remains unclear whether IBS and each of its subtypes (predominant diarrhea IBS-D, constipation IBS-C, mixed IBS-M) are associated with higher anxiety and depressive symptoms levels. This study aimed to determine the associations of IBS and each of its subtypes with anxiety and/or depression. We conducted a systematic review and meta-analysis using five electronic databases (PubMed, PsychINFO, BIOSIS, Science Direct, and Cochrane CENTRAL). We selected case–control studies comparing anxiety and depression levels of patients with IBS to healthy controls, using standardized rating scales. Outcomes were measured as random pooled standardized mean differences (SMD). Ten studies were included in our analysis (885 patients and 1,384 healthy controls). Patients with IBS had significant higher anxiety and depression levels than controls (respectively, SMD = 0.76, 95 % CI 0.47; 0.69, p < 0.01, I2 = 81.7 % and SMD = 0.80, 95 % CI 0.42; 1.19, p < 0.01, I2 = 90.7 %). This significant difference was confirmed for patients with IBS-C and -D subtypes for anxiety, and only in IBS-D patients for depression. However, other IBS subtypes had a statistical trend to be associated with both anxiety and depressive symptomatology, which suggests a lack of power due to the small number of studies included. Patients with IBS had significantly higher levels of anxiety and depression than healthy controls. Anxiety and depression symptomatology should be systematically checked and treated in IBS patients, as psychological factors are important moderators of symptom severity, symptom persistence, decisions to seek treatment, and response to treatment.


Irritable bowel syndrome Anxiety Depression Psychiatric comorbidities 



This work was supported by INSERM, Assistance Publique - Hôpitaux de Paris, RTRS Santé Mentale (Fondation Fondamental), and by Agence Nationale pour la Recherche (ANR: NEURO 2009, V.I.P. project). This work was supported (in part) by the Investissements d’Avenir program managed by the ANR under reference ANR-11-IDEX-0004-02.

Conflict of interest

No conflicts to disclose.

Supplementary material

406_2014_502_MOESM1_ESM.docx (77 kb)
Supplementary material 1 (DOCX 77 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Guillaume Fond
    • 1
    • 5
    Email author
  • Anderson Loundou
    • 2
  • Nora Hamdani
    • 1
  • Wahid Boukouaci
    • 4
  • Aroldo Dargel
    • 3
    • 4
  • José Oliveira
    • 4
  • Matthieu Roger
    • 1
  • Ryad Tamouza
    • 4
  • Marion Leboyer
    • 1
  • Laurent Boyer
    • 2
  1. 1.Pôle de psychiatrie des hôpitaux universitaires H Mondor, DHU Pe-Psy, INSERM U955, Eq Psychiatrie Génétique, Fondation FondaMental Fondation de coopération scientifique en santé mentaleUniversité Paris EstCréteilFrance
  2. 2.EA 3279-Self-perceived Health Assessment Research Unit, School of MedicineLa Timone UniversityMarseilleFrance
  3. 3.Laboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto AlegreINCT for Translational MedicinePorto AlegreBrazil
  4. 4.Jean Dausset Laboratory and INSERM, UMRS 940Hôpital Saint LouisParisFrance
  5. 5.Pole de PsychiatrieHôpital A. ChenevierCréteilFrance

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