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Modulating neural plasticity with non-invasive brain stimulation in schizophrenia

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Abstract

Schizophrenia is a severe mental disorder characterised by a complex phenotype including positive, negative, affective and cognitive symptoms. Various theories have been developed to integrate the clinical phenotype into a strong neurobiological framework. One theory describes schizophrenia as a disorder of impaired neural plasticity. Recently, non-invasive brain stimulation techniques have garnered much attention to their ability to modulate plasticity and treat schizophrenia. The aim of this review is to introduce the basic physiological principles of conventional non-invasive brain stimulation techniques and to review the available evidence for schizophrenia. Despite promising evidence for efficacy in a large number of clinical trials, we continue to have a rudimentary understanding of the underlying neurobiology. Additional investigation is required to improve the response rates to non-invasive brain stimulation, to reduce the interindividual variability and to improve the understanding of non-invasive brain stimulation in schizophrenia.

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Authors and Affiliations

  1. Deparment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstr 7, 80336, Munich, Germany

    Alkomiet Hasan & Berend Malchow

  2. Centre of Mental Health, Darmstadt-Dieburg Clinics, Groß-Umstadt, Germany

    Thomas Wobrock

  3. Department of Psychiatry and Psychotherapy, Georg-August University, Göttingen, Germany

    Thomas Wobrock

  4. Temerty Centre for Therapeutic Brain Intervention and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada

    Tarek Rajji & Zafiris J. Daskalakis

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  1. Alkomiet Hasan
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  2. Thomas Wobrock
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  5. Zafiris J. Daskalakis
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Hasan, A., Wobrock, T., Rajji, T. et al. Modulating neural plasticity with non-invasive brain stimulation in schizophrenia. Eur Arch Psychiatry Clin Neurosci 263, 621–631 (2013). https://doi.org/10.1007/s00406-013-0446-8

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