Abstract
The German Association for Psychiatry and Psychotherapy (DGPPN) has committed itself to establish a prospective national cohort of patients with major psychiatric disorders, the so-called DGPPN-Cohort. This project will enable the scientific exploitation of high-quality data and biomaterial from psychiatric patients for research. It will be set up using harmonised data sets and procedures for sample generation and guided by transparent rules for data access and data sharing regarding the central research database. While the main focus lies on biological research, it will be open to all kinds of scientific investigations, including epidemiological, clinical or health-service research.
References
Tsuang M (2000) Schizophrenia: genes and environment. Biol Psychiatry 47(3):210–220
Lee KW, Woon PS, Teo YY, Sim K (2012) Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt? Neurosci Biobehav Rev 36(1):556–571. doi:10.1016/j.neubiorev.2011.09.001
Williams HJ, Owen MJ, O’Donovan MC (2009) Schizophrenia genetics: new insights from new approaches. Br Med Bull 91:61–74. doi:10.1093/bmb/ldp017
Bondy B (2003) Common genetic risk factors for psychiatric and simatic disorders. Dialogues Clin Neurosci 5(2):129–138
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, König IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Müller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpeläinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Paré G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietiläinen KH, Pouta A, Ridderstråle M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kähönen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimäki T, Melander O, Mosley TH, Musk AW, Nieminen MS, O’Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tönjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Grönberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Völzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O’Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467(7317):832–838. doi:10.1038/nature09410
Sullivan PF (2010) The psychiatric GWAS consortium: big science comes to psychiatry. Neuron 68(2):182–186
Wray NR, Visscher PM (2010) Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull 36(1):14–23
Salokangas RK, Nieman DH, Heinimaa M, Svirskis T, Luutonen S, From T, von Reventlow HG, Juckel G, Linszen D, Dingemans P, Birchwood M, Patterson P, Schultze-Lutter F, Klosterkotter J, Ruhrmann S (2012) Psychosocial outcome in patients at clinical high risk of psychosis: a prospective follow-up. Soc Psychiatry Psychiatr Epidemiol. doi:10.1007/s00127-012-0545-2
Johnstone EC, Russell KD, Harrison LK, Lawrie SM (2003) The Edinburgh high risk study: current status and future prospects. World Psychiatry 2(1):45–49
David AS, Zammit S, Lewis G, Dalman C, Allebeck P (2008) Impairments in cognition across the spectrum of psychiatric disorders: evidence from a Swedish conscript cohort. Schizophr Bull 34(6):1035–1041. doi:10.1093/schbul/sbn028
Manrique-Garcia E, Zammit S, Dalman C, Hemmingsson T, Andreasson S, Allebeck P (2012) Cannabis, schizophrenia and other non-affective psychoses: 35 years of follow-up of a population-based cohort. Psychol Med 42(6):1321–1328. doi:10.1017/s0033291711002078
Lonnqvist JE, Verkasalo M, Haukka J, Nyman K, Tiihonen J, Laaksonen I, Leskinen J, Lonnqvist J, Henriksson M (2009) Premorbid personality factors in schizophrenia and bipolar disorder: results from a large cohort study of male conscripts. J Abnorm Psychol 118(2):418–423. doi:10.1037/a0015127
Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE, Ioannidis JP, Stefanis CN (2007) Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry 62(7):784–792. doi:10.1016/j.biopsych.2006.11.015
Malaspina D, Corcoran C, Kleinhaus KR, Perrin MC, Fennig S, Nahon D, Friedlander Y, Harlap S (2008) Acute maternal stress in pregnancy and schizophrenia in offspring: a cohort prospective study. BMC Psychiatry 8:71
Niebuhr DW, Millikan AM, Cowan DN, Yolken R, Li Y, Weber NS (2008) Selected infectious agents and risk of schizophrenia among U.S. military personnel. Am J Psychiat 165(1):99–106. doi:10.1176/appi.ajp.2007.06081254
Centre for Longitudinal Studies Institute of Education, University of London (2012) http://www.cls.ioe.ac.uk/. Accessed 18/07/2012
Danish National Birth Cohort SSI (2013) http://www.ssi.dk/English/RandD/Research%20areas/Epidemiology/DNBC/. Accessed 19/07/2012
Northern Finland Birth Cohort Studies NFBC, University of Oulu (2013) http://kelo.oulu.fi/NFBC/. Accessed 17/08/2012
Mater-University of Queensland Study of Pregnancy (MUSP) The University of Queensland, Australia (2012) http://www.socialscience.uq.edu.au/musp. Accessed 18/07/2013
UK Biobank (2013) http://www.ukbiobank.ac.uk/. Accessed 20/07/2012
Danish National Biobank (2013) http://www.ssi.dk/English/Service/AboutSSI/Organization/Organisationchart/Department.aspx?id=e4091b0d-0269-4445-9fe5-9db500a0483e. Accessed 19/07/2012
National Biobank of Finland (2012) http://www.nationalbiobanks.fi/. Accessed 18/07/2012
National Biobanking Programme of Sweden (2003) http://www.biobanks.se/. Accessed 20/07/2012
Kim H, Yi BK, Kim IK, Kwak YS (2011) Integrating clinical information in National Biobank of Korea. J Med Syst 35(4):647–656. doi:10.1007/s10916-009-9402-6
Kaiser Permanente HUGE Project (2013) https://rpgeh-enroll.kaiserpermanente.org/Guest/Default.aspx. Accessed 18/07/2012
Nationale Kohorte (2013) www.nationale-kohorte.de. Accessed 10/01/2013
Moods Initiative (2013) http://www.ngfn-moods.de. Accessed 15/09/2012
TMF (2013) (Technologie- und Methodenplattform für die vernetzte medizinische Forschung). http://www.tmf-ev.de. Accessed 17/07/2012
Acknowledgments
This work is supported by the Deutsche Forschungsgemeinschaft (DFG) via the Clinical Research Group 241 “Genotype–phenotype relationships and neurobiology of the longitudinal course of psychosis” (http://www.kfo241.de; grant number SCHU 1603/5-1).
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The authors declare no conflict of interest.
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Anderson-Schmidt, H., Adler, L., Aly, C. et al. The “DGPPN-Cohort”: a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients. Eur Arch Psychiatry Clin Neurosci 263, 695–701 (2013). https://doi.org/10.1007/s00406-013-0401-8
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DOI: https://doi.org/10.1007/s00406-013-0401-8