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Differential expression of HINT1 in schizophrenia brain tissue

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Abstract

Recent findings in the literature suggest a relation between histidine triad nucleotide-binding protein-1 (HINT1) and psychiatric disorders such as major depression, anxiety, and schizophrenia, although its physiological roles are not completely comprehended. Using Western blot, we compared HINT1 protein expression in the postmortem dorsolateral prefrontal cortex and thalamus of schizophrenia patients and healthy controls for contributing to elucidate the role of HINT1 in schizophrenia pathophysiology. HINT1 was found to be downregulated in the dorsolateral prefrontal cortex and upregulated in the thalamus. Our results combined to previous studies in human samples and preclinical models support the notion that HINT1 must be more explored as a potential target for psychiatric disorders.

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Acknowledgments

We thank the tissue donors and their families. We also thank Manfred Bauer for brain preparation and Udo Rueb for Braak staging.

Conflict of interest

All authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany

    Jeeva Varadarajulu, Christoph W. Turck & Daniel Martins-de-Souza

  2. Department of Psychiatry, University of Goettingen, Von Siebold Str. 5, 37075, Goettingen, Germany

    Andrea Schmitt & Peter Falkai

  3. Lab. de Neurociências (LIM-27), Inst. Psiquiatria, Fac. de Medicina da, Universidade de São Paulo, São Paulo, SP, Brazil

    Andrea Schmitt & Daniel Martins-de-Souza

  4. Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB 2 1QT, UK

    Murtada Alsaif & Daniel Martins-de-Souza

Authors
  1. Jeeva Varadarajulu
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  2. Andrea Schmitt
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  3. Peter Falkai
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  4. Murtada Alsaif
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  5. Christoph W. Turck
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  6. Daniel Martins-de-Souza
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Corresponding author

Correspondence to Daniel Martins-de-Souza.

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Varadarajulu, J., Schmitt, A., Falkai, P. et al. Differential expression of HINT1 in schizophrenia brain tissue. Eur Arch Psychiatry Clin Neurosci 262, 167–172 (2012). https://doi.org/10.1007/s00406-011-0216-4

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  • DOI: https://doi.org/10.1007/s00406-011-0216-4

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