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Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients

Abstract

Deficits in executive functions, e.g. voluntary selection, are considered central to the attention-deficit/hyperactivity disorder (ADHD). The aim of this simultaneous EEG/fMRI study was to examine associated neural correlates in ADHD patients. Patients with ADHD and healthy subjects performed an adapted go/nogo task including a voluntary selection condition allowing participants to freely decide, whether to press the response button. Electrophysiologically, response inhibition and voluntary selection led to fronto-central responses. The fMRI data revealed increased medial/lateral frontal and parietal activity during the voluntary selection task. Frontal brain responses were reduced in ADHD patients compared to controls during free responses, whereas parietal brain functions seemed to be unaffected. These results may indicate that selection processes are related to dysfunctions, predominantly in frontal brain regions in ADHD patients.

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Acknowledgments

This study is part of the MD thesis of Tobias Thalmeier at the Faculty of Medicine, Ludwig-Maximilians-University, Munich. We thank Mije Hartmann who assisted with the proof-reading of the manuscript. All authors reported no biomedical financial interest or potential conflict of interest. This study was supported by the Faculty of Medicine, University of Munich (Förderprogramm für Forschung und Lehre; FöFoLe-572).

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Correspondence to Susanne Karch.

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Karch, S., Thalmeier, T., Lutz, J. et al. Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients. Eur Arch Psychiatry Clin Neurosci 260, 427–440 (2010). https://doi.org/10.1007/s00406-009-0089-y

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Keywords

  • Voluntary selection
  • ADHD
  • EEG–fMRI