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Finding gene-environment interactions for phobias

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Abstract

Phobias are common disorders causing a great deal of suffering. Studies of gene-environment interaction (G × E) have revealed much about the complex processes underlying the development of various psychiatric disorders but have told us little about phobias. This article describes what is already known about genetic and environmental influences upon phobias and suggests how this information can be used to optimise the chances of discovering G × Es for phobias. In addition to the careful conceptualisation of new studies, it is suggested that data already collected should be re-analysed in light of increased understanding of processes influencing phobias.

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References

  1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington, DC

    Google Scholar 

  2. Bolton D, Eley TC, O’Connor TG, Perrin S, Rabe-Hesketh S, Rijsdijk F, Smith P (2006) Prevalence and genetic and environmental influences on anxiety disorders in 6-year-old twins. Psychol Med 36:335–344

    Article  PubMed  Google Scholar 

  3. Caspi A, Moffitt TE (2006) Opinion: gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 7:583–590

    Article  PubMed  CAS  Google Scholar 

  4. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389

    Article  PubMed  CAS  Google Scholar 

  5. Eley TC, Bolton D, O’Connor TG, Perrin S, Smith P, Plomin R (2003) A twin study of anxiety-related behaviours in pre-school children. J Child Psychol Psychiatry 44:945–960

    Article  PubMed  Google Scholar 

  6. Field AP, Lawson J (2003) Fear information and the development of fears during childhood: effects on implicit fear responses and behavioural avoidance. Behav Res Ther 41:1277–1293

    Article  PubMed  CAS  Google Scholar 

  7. Finlay-Jones R, Brown GW (1981) Types of stressful life events and the onset of anxiety and depressive disorders. Psychol Med 11:803–815

    PubMed  CAS  Google Scholar 

  8. Furmark T, Tillfors M, Garpenstrand H, Marteinsdottir I, Langstrom B, Oreland L, Fredrikson M (2004) Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett 362:189–192

    Article  PubMed  CAS  Google Scholar 

  9. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645

    Article  PubMed  Google Scholar 

  10. Gregory AM, Caspi A, Moffitt TE, Koenen K, Eley TC, Poulton R (2007) Juvenile mental health histories of adults with anxiety disorders. Am J Psychiatry 164:301–308

    Article  PubMed  Google Scholar 

  11. Hettema JM, Annas P, Neale MC, Kendler KS, Fredrikson M (2003) A twin study of the genetics of fear conditioning. Arch Gen Psychiatry 60:702–708

    Article  PubMed  Google Scholar 

  12. Hettema JM, Prescott CA, Kendler KS (2003) The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder. Psychol Med 33:1423–1432

    Article  PubMed  CAS  Google Scholar 

  13. Hettema JM, Prescott CA, Myers JM, Neale MC, Kendler KS (2005) The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 62:182–189

    Article  PubMed  Google Scholar 

  14. Kendler KS, Jacobson KC, Myers J, Prescott CA (2002) Sex differences in genetic and environmental risk factors for irrational fears and phobias. Psychol Med 32:209–217

    Article  PubMed  CAS  Google Scholar 

  15. Kendler KS, Karkowski LM, Prescott CA (1999) Fears and phobias: reliability and heritability. Psychol Med 29:539–553

    Article  PubMed  CAS  Google Scholar 

  16. Kendler KS, Myers J, Prescott CA (2002) The etiology of phobias—an evaluation of the stress-diathesis model. Arch Gen Psychiatry 59:242–248

    Article  PubMed  Google Scholar 

  17. Kendler KS, Myers J, Prescott CA, Neale MC (2001) The genetic epidemiology of irrational fears and phobias in men. Arch Gen Psychiatry 58:257–265

    Article  PubMed  CAS  Google Scholar 

  18. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1993) Major depression and phobias: the genetic and environmental sources of comorbidity. Psychol Med 23:361–371

    Article  PubMed  CAS  Google Scholar 

  19. Kendler KS, Prescott CA, Myers J, Neale MC (2003) The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 60:929–937

    Article  PubMed  Google Scholar 

  20. Kendler KS, Walters EE, Truett KR, Heath AC, Neale MC, Martin NG, Eaves LJ (1995) A twin-family study of self-report symptoms of panic-phobia and Somatization. Behav Genet 25:499–515

    Article  PubMed  CAS  Google Scholar 

  21. Kessler RC, Berglund P, Demler O, Jin R, Walters EE (2005) Lifetime prevalence and age-of-onset distributions’ of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62:593–602

    Article  PubMed  Google Scholar 

  22. Kessler RC, Chiu WT, Demler O, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617–627

    Article  PubMed  Google Scholar 

  23. Krueger RF (1999) The structure of common mental disorders. Arch Gen Psychiatry 56:921–926

    Article  PubMed  CAS  Google Scholar 

  24. Lichtenstein P, Annas P (2000) Heritability and prevalence of specific fears and phobia in childhood. J Child Psychol Psychiatry 41:927–937

    Article  PubMed  CAS  Google Scholar 

  25. McGrath M, Kawachi I, Ascherio A, Colditz GA, Hunter DJ, De Vivo I (2004) Association between catechol-O-methyltransferase and phobic anxiety. Am J Psychiatry 161:1703–1705

    Article  PubMed  Google Scholar 

  26. Nelson EC, Grant JD, Bucholz KK, Glowinski A, Madden PAF, Reich W, Heath AC (2000) Social phobia in population-based female adolescent twin sample: co-morbidity and associated suicide-related symptoms. Psychol Med 30:797–804

    Article  PubMed  CAS  Google Scholar 

  27. Philibert R, Caspers K, Langbehn D, Troughton EP, Yucuis R, Sandhu HK, Cadoret RJ (2002) The association of a HOPA polymorphism with major depression and phobia. Compr Psychiatry 43:404–410

    Article  PubMed  Google Scholar 

  28. Pine DS, Cohen P, Gurley D, Brook J, Ma YJ (1998) The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry 55:56–64

    Article  PubMed  CAS  Google Scholar 

  29. Plomin R, DeFries JC, McClearn GE, McGuffin P (2001) Behavioral genetics 4th edn. Worth Publishers, New York

    Google Scholar 

  30. Poulton R, Menzies RG (2002) Non-associative fear acquisition: a review of the evidence from retrospective and longitudinal research. Behav Res Ther 40:127–149

    Article  PubMed  Google Scholar 

  31. Rachman SJ (1978) Fear and courage, WH Freeman & Co., San Francisco

    Google Scholar 

  32. Rijsdijk FV, Sham PC (2002) Analytic approaches to twin data using structural equation models. Brief Bioinformatics 3:119–133

    Article  PubMed  CAS  Google Scholar 

  33. Rutter M (2006) Gene-environment interplay in Genes and Behaviour, Blackwell, Oxford, pp 178–210

    Google Scholar 

  34. Safren SA, Gershuny BS, Marzol P, Otto MW, Pollack MH (2002) History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder. J Nerv Ment Dis 190:453–456

    Article  PubMed  Google Scholar 

  35. Seligman ME (1971) Phobias and preparedness. Behav Ther 2:307–320

    Article  Google Scholar 

  36. Silberg JL, Rutter M, Eaves L (2001) Genetic and environmental influences on the temporal association between earlier anxiety and later depression in girls. Biol Psychiatry 49:1040–1049

    Article  PubMed  CAS  Google Scholar 

  37. Simonoff E, Pickles A, Meyer J, Silberg JL, Maes H, Loeber R, Rutter M, Hewitt JK, Eaves LJ (1997) The Virginia twin study of adolescent behavioral development. Influences of age, sex, and impairment on rates of disorder. Arch Gen Psychiatry 54:801–808

    PubMed  CAS  Google Scholar 

  38. Skre I, Onstad S, Torgersen S, Lygren S, Kringlen E (2000) The heritability of common phobic fear: a twin study of a clinical sample. J Anxiety Disord 14:549–562

    Article  PubMed  CAS  Google Scholar 

  39. Smoller JW, Tsuang MT (1998) Panic and phobic anxiety: defining phenotypes for genetic studies. Am J Psychiatry 155:1152–1162

    PubMed  CAS  Google Scholar 

  40. Stein MB, Jang KL, Livesley WJ (2002) Heritability of social anxiety-related concerns and personality characteristics: a twin study. J Nerv Ment Dis 190:219–224

    Article  PubMed  Google Scholar 

  41. Stein MB, Walker JR, Anderson G, Hazen AL, Ross CA, Eldridge G, Forde DR (1996) Childhood physical and sexual abuse in patients with anxiety disorders and in a community sample. Am J Psychiatry 153:275–277

    PubMed  CAS  Google Scholar 

  42. Stevenson J, Batten N, Cherner M (1992) Fears and fearfulness in children and adolescents: a genetic analysis of twin data. J Child Psychol Psychiatry 33:977–985

    Article  PubMed  CAS  Google Scholar 

  43. Vollebergh WAM, Iedema J, Bijl RV, de Graaf R, Smit F, Ormel J (2001) The structure and stability of common mental disorders—the NEMESIS study. Arch Gen Psychiatry 58:597–603

    Article  PubMed  CAS  Google Scholar 

  44. Watson D (2005) Rethinking the mood and anxiety disorders: a quantitative hierarchical model for DSM-V. J Abnorm Psychol 114:522–536

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Thalia C. Eley is funded by a Medical Research Council Career Development Award. The authors thank Megan Crawford, Jessica Holland and Thomas Willis for their feedback on an earlier draft of this manuscript and for their assistance in preparing this article.

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Correspondence to Alice M. Gregory.

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Gregory, A.M., Lau, J.Y.F. & Eley, T.C. Finding gene-environment interactions for phobias. Eur Arch Psychiatry Clin Neurosc 258, 76–81 (2008). https://doi.org/10.1007/s00406-007-0786-3

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