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Gene-environment interaction and the anxiety disorders

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References

  1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. APA, Washington, DC

    Google Scholar 

  2. Andrews G, Craig A, Feyer AM, Hoddinott S, Howie P, Neilson M (1983) Stuttering: a review of research findings and theories circa 1982. J Speech Hear Disord 48:226–246

    PubMed  CAS  Google Scholar 

  3. Andrews G, Slade T, Issakidis C (2002) Deconstructing current comorbidity: data from the Australian National Survey of Mental Health and Well-Being. Br J Psychiatry 181:306–314

    PubMed  Article  Google Scholar 

  4. Andrews G, Stewart G, Morris-Yates A, Holt P, Henderson S (1990) Evidence for a general neurotic syndrome. Br J Psychiatry 157:6–12

    PubMed  CAS  Article  Google Scholar 

  5. Ben-Shlomo Y, Kuh D (2002) A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives. Int J Epidemiol 31:285–293

    PubMed  Article  Google Scholar 

  6. Caspi A, McClay J, Moffitt TE, Mill JS, Martin J, Craig I, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297:851–854

    PubMed  Article  CAS  Google Scholar 

  7. Caspi A, Moffitt TE (2006) Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 7:583–590

    PubMed  Article  CAS  Google Scholar 

  8. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig I, Harrington HL, McClay J, Mill JS, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389

    PubMed  Article  CAS  Google Scholar 

  9. Cox BJ, Clara IP, Enns MW (2002) Posttraumatic stress disorder and the structure of common mental disorders. Depress Anxiety 15:168–171

    PubMed  Article  Google Scholar 

  10. Haslam N, Williams BJ, Kyrios M, McKay MD, Taylor S (2005) Subtyping obsessive-compulsive disorder: a taxometric analysis. Behav Ther 36:381–391

    Article  Google Scholar 

  11. Helzer J, Kraemer HC, Krueger R, Wittchen HU, Sirovatka P, Regier DA (2007) Dimensional approaches in diagnostic classification—a critical appraisal: refining the research agenda for DSM-V. American Psychiatric Press Inc., Arlington, VA

    Google Scholar 

  12. Henry B, Moffitt TE, Caspi A, Langley JD, Silva PA (1994) On the “remembrance of things past”: a longitudinal evaluation of the retrospective method. Psychol Assess 6:92–101

    Article  Google Scholar 

  13. Hettema JM, Annas P, Neale MC, Kendler KS, Fredrikson M (2003) A twin study of the genetics of fear conditioning. Arch Gen Psychiatry 60:702–708

    PubMed  Article  Google Scholar 

  14. Hymen SE (2007) Can neuroscience be integrated into the DSM-IV? Nat Rev Neurosci 8:725–732

    Article  CAS  Google Scholar 

  15. Jaffee SR, Caspi A, Moffitt TE, Polo-Tomas M, Taylor A (2007) Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors model. Child Abuse Negl 31:231–253

    PubMed  Article  Google Scholar 

  16. Kendler KS, Baker JH (2007) Genetic influences on measures of the environment: a systematic review. Psychol Med 37:615–626

    PubMed  Article  Google Scholar 

  17. Kendler KS, Hettema JM, Butera F, Gardner CO, Prescott CA (2003) Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry 60:789–796

    PubMed  Article  Google Scholar 

  18. Kendler KS, Myers J, Prescott CA (2002) The etiology of phobias: an evaluation of the stress-diathesis model. Arch Gen Psychiatry 59:242–248

    PubMed  Article  Google Scholar 

  19. Kendler KS, Prescott CA, Myers J, Neale MC (2003) The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 60:929–937

    PubMed  Article  Google Scholar 

  20. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617–627

    PubMed  Article  Google Scholar 

  21. Koenen K, Moffitt TE, Poulton R, Martin J, Caspi A (2007) Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort. Psychol Med 37:181–192

    PubMed  Article  Google Scholar 

  22. Kollman DM, Brown TA, Liverant GI, Hofmann SG (2006) A taxometric investigation of the latent structure of social anxiety disorder in outpatients with anxiety and mood disorders. Depress Anxiety 23:190–199

    PubMed  Article  Google Scholar 

  23. Krueger RF (1999) The structure of common mental disorders. Arch Gen Psychiatry 56:921–926

    PubMed  Article  CAS  Google Scholar 

  24. Krueger RF, Caspi A, Moffitt TE, Silva PA (1998) The structure and stability of common mental disorders (DSM-III-R): a longitudinal-epidemiological study. J Abnorm Psychol 107:216–227

    PubMed  Article  CAS  Google Scholar 

  25. Krueger RF, Chentsova-Dutton YE, Markon KE, Goldberg D, Ormel J (2003) A cross-cultural study of the structure of comorbidity among common psychopathological syndromes in the general health care setting. J Abnorm Psychol 112:437–447

    PubMed  Article  Google Scholar 

  26. Krueger RF, McGrue M, Iacono WG (2001) The higher order structure of common DSM mental disorders: internalization, externalization, and their connections to personality. Pers Individ Dif 30:1245–1259

    Article  Google Scholar 

  27. Marks IM (1987) Fears, phobias and rituals: panic, anxiety and their disorders. Oxford University Press, New York

    Google Scholar 

  28. Marks IM, Nesse RM (1994) Fear and fitness: an evolutionary analysis of anxiety disorders. Ethol Sociobiol 15:247–261

    Article  Google Scholar 

  29. McNally RJ (2000) Emotion research in cognitive-behavior therapy: obstacles to application. Clin Psychol Sci Pract 7:400–402

    Article  Google Scholar 

  30. Mineka S, Zinbarg R (2006) A contemporary learning theory perspective on the etiology of anxiety disorders: it’s not what you thought it was. Am Psychol 61:10–26

    PubMed  Article  Google Scholar 

  31. Moffitt TE, Caspi A, Harrington HL, Milne BJ, Melchior M, Goldberg D, Poulton R (2007) Generalized anxiety disorder and depression: childhood risk factors in a birth cohort followed to age 32. Psychol Med 37:441–452

    PubMed  Article  Google Scholar 

  32. Moffitt TE, Caspi A, Rutter M (2005) Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 62:473–481

    PubMed  Article  CAS  Google Scholar 

  33. Newman DL, Moffitt TE, Caspi A, Silva PA (1998) Comorbid mental disorders: implications for clinical treatment and sample selection. J Abnorm Psychol 107:305–311

    PubMed  Article  CAS  Google Scholar 

  34. Plomin R, DeFries JC, Loehlin JC (1977) Genotype–environment interaction and correlation in the analysis of human behavior. Psychol Bull 84:309–322

    PubMed  Article  CAS  Google Scholar 

  35. Poulton R, Davies S, Menzies RG, Langley JD, Silva PA (1998) Evidence for a non-associative model of the acquisition of a fear of heights. Behav Res Ther 36:537–544

    PubMed  Article  CAS  Google Scholar 

  36. Poulton R, Grisham JR, Andrews G (2007) Developmental approaches to understanding anxiety disorders. In: Antony MM, Stein MB (eds) Oxford handbook of anxiety and related disorders. Oxford University Press, Oxford (in press)

  37. Poulton R, Menzies RG (2002) Non-associative fear acquisition: a review of the evidence from retrospective and longitudinal research. Behav Res Ther 40:127–149

    PubMed  Article  Google Scholar 

  38. Rachman SJ (1978) Fear and courage, 2nd edn. Freeman, San Francisco

    Google Scholar 

  39. Rapee RM, Spence SH (2004) The etiology of social phobia: empirical evidence and an initial model. Clin Psychol Rev 24:737–767

    PubMed  Article  Google Scholar 

  40. Robins LN (2004) Using survey results to improve the validity of the standard psychiatric nomenclature. Arch Gen Psychiatry 61:1188–1194

    PubMed  Article  Google Scholar 

  41. Ruscio AM, Borkovec TD, Ruscio J (2001) A taxometric investigation of the latent structure of worry. J Abnorm Psychol 110:413–422

    PubMed  Article  CAS  Google Scholar 

  42. Ruscio AM, Ruscio J, Keane TM (2002) The latent structure of posttraumatic stress disorder: a taxometric investigation of reactions to extreme stress. J Abnorm Psychol 111:290–301

    PubMed  Article  Google Scholar 

  43. Rushton JP, Brainerd CJ, Pressley M (1993) Behavioural development and construct validity: the principle of aggregation. Psychol Bull 94:18–38

    Article  Google Scholar 

  44. Rutter M, Moffitt TE, Caspi A (2006) Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry 47:226–261

    PubMed  Article  Google Scholar 

  45. Rutter M, Pickles A, Murray R, Eaves L (2001) Testing hypotheses on specific environmental causal effects on behavior. Psychol Bull 127:291–324

    PubMed  Article  CAS  Google Scholar 

  46. Slade T, Andrews G (2001) DSM-IV and ICD-10 generalized anxiety disorder: discrepant diagnoses and associated disability. Soc Psychiatry Psychiatr Epidemiol 36:45–51

    PubMed  Article  CAS  Google Scholar 

  47. Slade T, Watson D (2006) The structure of common DSM-IV and ICD-10 mental disorders in the Australian general population. Psychol Med 36:1593–1600

    PubMed  Article  Google Scholar 

  48. Storr CL, Ialongo NS, Anthony JC, Breslau N (2007) Childhood antecedents of exposure to traumatic events and posttraumatic stress disorder. Am J Psychiatry 164:119–125

    PubMed  Article  Google Scholar 

  49. Vollebergh WA, Iedema J, Bijl RV, de Graaf R, Smit F, Ormel J (2001) The structure and stability of common mental disorders: the NEMESIS study. Arch Gen Psychiatry 58:597–603

    PubMed  Article  CAS  Google Scholar 

  50. Watson D (2005) Rethinking the mood and anxiety disorders: a quantitative hierarchical model for DSM-V. J Abnorm Psychol 114:522–536

    PubMed  Article  Google Scholar 

  51. Wong MY, Day NE, Luan JA, Chan KP, Wareham NJ (2003) The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol 32:51–57

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Richie Poulton.

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Poulton, R., Andrews, G. & Millichamp, J. Gene-environment interaction and the anxiety disorders. Eur Arch Psychiatry Clin Neurosc 258, 65–68 (2008). https://doi.org/10.1007/s00406-007-0784-5

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Keywords

  • Anxiety Disorder
  • Obsessive Compulsive Disorder
  • Social Phobia
  • Panic Disorder
  • Obsessive Compulsive Disorder