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Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations

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Abstract

We examined alteration of regional cerebral blood flow (rCBF) in a case of Alzheimer's disease (AD) patient with musical hallucination. To detect regions related to musical hallucination, single–photon emission computed tomography (SPECT) imaging of the patient and nine sex, age, and cognitive functionmatched AD patients without delusions and hallucinations were compared using statistical parametric mapping 99 (SPM99). In comparison with controls, the patient had increased rCBF in left temporal regions and left angular gyrus. This profile could be relevant to the neuroanatomical basis of musical hallucinations.

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Authors and Affiliations

  1. Department of Neuropsychiatry, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan

    T. Mori MD, M. Ikeda MD, PhD, R. Fukuhara MD, PhD, N. Matsumoto MD & H. Tanabe MD, PhD

  2. Department of Radiology, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan

    Y. Sugawara MD, PhD & S. Nakata RT

  3. University of Cambridge Neurology Unit, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK

    P. J. Nestor PhD, FRACP

Authors
  1. T. Mori MD
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  2. M. Ikeda MD, PhD
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  3. R. Fukuhara MD, PhD
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  4. Y. Sugawara MD, PhD
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  5. S. Nakata RT
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  6. N. Matsumoto MD
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  7. P. J. Nestor PhD, FRACP
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  8. H. Tanabe MD, PhD
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Corresponding author

Correspondence to M. Ikeda MD, PhD.

Additional information

This work had been carried out at the Higher Brain Function Clinic of the Ehime University Hospital.

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Mori, T., Ikeda, M., Fukuhara, R. et al. Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations. Eur Arch Psychiatry Clin Neurosci 256, 236–239 (2006). https://doi.org/10.1007/s00406-005-0631-5

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  • DOI: https://doi.org/10.1007/s00406-005-0631-5

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