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Cerebral networks linked to the event-related potential P300

  • Helge HornEmail author
  • Nadeem Syed
  • Heinrich Lanfermann
  • Konrad Maurer
  • Thomas Dierks
ORIGINAL PAPER

Abstract.

P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the P300 component. In the present study we could demonstrate a network of P300 generators. Investigated were 15 healthy subjects with an acoustical oddball paradigm within a fMRI block design, which enabled us to exclude attention or acoustical processing effects. The inferior and middle frontal, superior temporal, lower parietal cortex, the insula and the anterior cingulum were significantly activated symmetrical in both hemispheres.

Key words

P3  P3 generators  event related potentials oddball paradigm working memory 

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Copyright information

© Steinkopff Verlag 2003

Authors and Affiliations

  • Helge Horn
    • 1
    Email author
  • Nadeem Syed
    • 2
  • Heinrich Lanfermann
    • 3
  • Konrad Maurer
    • 2
  • Thomas Dierks
    • 1
  1. 1.Dept. of Psychiatric NeurophysiologyUniversity Hospital of Clinical Psychiatry Bern BernSwitzerland
  2. 2.Clin. Neurophysiology Laboratory Dept. of Psychiatry IUniv. of FrankfurtGermany
  3. 3.Dept. of NeuroradiologyUniv. of FrankfurtGermany

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