Abstract
Taurine is a β-aminosulfonic acid and is a ubiquitous amino acid whose role in the cochlea is not well established. In this study, its entry from blood into perilymph was investigated in the guinea pig as animal model. The penetration rate of [3H]taurine (molecular weight 125) into the perilymph of the scala vestibuli was measured 1 and 2 h after the intravenous infusion of [3H]taurine in nephrectomized animals. Results showed a rate of penetration in perilymph related to plasma at 36 ± 4.7% (n = 5) after 1 h and 43 ± 5.6% (n = 5) after 2 h. Compared to the penetration rate of urea (molecular weight 60) and mannitol (molecular weight 186) reported previously in rats, a passive entry of taurine into perilymph through the blood-perilymph barrier is suggested.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 30 July 1997 / Accepted: 15 January 1998
Rights and permissions
About this article
Cite this article
Angelini, E., Teixeira, M., Aran, JM. et al. Taurine entry into perilymph of the guinea pig. European Archives of Oto-Rhino-Laryngology 255, 331–333 (1998). https://doi.org/10.1007/s004050050071
Issue Date:
DOI: https://doi.org/10.1007/s004050050071