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Comparative analysis of vestibular endolymphatic hydrops grading methods and hearing loss in Ménière’s disease: a retrospective MRI study using 3D-real inversion recovery sequence

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To compare the correlation between different grading methods of vestibular endolymphatic hydrops (EH) and the severity of hearing loss in Ménière’s disease (MD), and evaluate the diagnostic value of these methods in diagnosing MD.

Methods

This retrospective study included 30 patients diagnosed with MD from June 2021 to August 2023. All patients underwent inner ear MR gadolinium-enhanced imaging using three-dimensional (3D)-real inversion recovery sequences and pure-tone audiometry. The EH levels were independently evaluated according to the classification methods outlined by Nakashima et al. (Acta Otolaryngol Suppl 5–8, 2009. https://doi.org/10.1080/00016480902729827) (M1), Fang et al. (J Laryngol Otol 126:454–459, 2012. https://doi.org/10.1017/S0022215112000060) (M2), Barath et al. (Am J Neuroradiol 35:1387–1392, 2014. https://doi.org/10.3174/ajnr.A3856), (M3), Liu et al. (Front Surg 9:874971, 2022. https://doi.org/10.3389/fsurg.2022.874971), (M4), and Bernaerts et al. (Neuroradiology 61:421–429, 2019. https://doi.org/10.1007/s00234-019-02155-7) (M5), with a subsequent comparison of interobserver agreement. After achieving a consensus, an analysis was performed to explore the correlations between vestibular EH grading using different methods, the average hearing thresholds at low-mid, high-, and full frequencies and clinical stages. The diagnostic capabilities of these methods for MD were then compared.

Results

The interobserver consistency of M2–M5 was superior to that of M1. The EH grading based on M4 showed a significant correlation with the average hearing thresholds at low-mid, high-, and full frequencies and clinical stages. M1, M2, M3, and M5 correlated with some parameters. A receiver operating characteristic curve analysis indicated that M5 significantly outperformed M1, M2, M3, and M4 in terms of diagnostic efficiency for MD.

Conclusion

M4 showed the strongest correlation with the degree of hearing loss in patients with MD, whereas M5 showed the highest diagnostic performance.

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Data availability

The data that support the findings of this study are available on request from the corresponding author.

References

  1. Hoskin JL (2022) Ménière’s disease: new guidelines, subtypes, imaging, and more. Curr Opin Neurol 35:90–97. https://doi.org/10.1097/WCO.0000000000001021

    Article  PubMed  Google Scholar 

  2. Connor SEJ, Pai I (2021) Endolymphatic hydrops magnetic resonance imaging in Ménière’s disease. Clin Radiol 76:76.e1-76.e19. https://doi.org/10.1016/j.crad.2020.07.021

    Article  CAS  PubMed  Google Scholar 

  3. Zhang W, Hui L, Zhang B, Ren L, Zhu J, Wang F, Li S (2021) The correlation between endolymphatic hydrops and clinical features of Meniere disease. Laryngoscope 131:E144–E150. https://doi.org/10.1002/lary.28576

    Article  CAS  PubMed  Google Scholar 

  4. Han A, Kontorinis G (2023) A systematic review on delayed acquisition of post-gadolinium magnetic resonance imaging in Ménière’s disease: imaging of the endolymphatic spaces. J Laryngol Otol 137:239–245. https://doi.org/10.1017/S0022215122001347

    Article  CAS  PubMed  Google Scholar 

  5. Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, & Society of Otorhinolaryngology Head and Neck Surgery Chinese Medical Association (2017) Guideline of diagnosis and treatment of Meniere disease (2017). Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 52:167–172. https://doi.org/10.3760/cma.j.issn.1673-0860.2017.03.002

    Article  Google Scholar 

  6. Iwasaki S, Shojaku H, Murofushi T, Seo T, Kitahara T, Origasa H, Watanabe Y, Suzuki M, Takeda N (2021) Diagnostic and therapeutic strategies for Meniere’s disease of the Japan Society for Equilibrium Research. Auris Nasus Larynx 48:15–22. https://doi.org/10.1016/j.anl.2020.10.009

    Article  PubMed  Google Scholar 

  7. Liu Y, Pyykkö I, Naganawa S, Marques P, Gürkov R, Yang J, Duan M (2022) Consensus on MR imaging of endolymphatic hydrops in patients with suspected hydropic ear disease (Meniere). Front Surg 9:874971. https://doi.org/10.3389/fsurg.2022.874971

    Article  PubMed  PubMed Central  Google Scholar 

  8. Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; & Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association (2020) The consensus of Chinese experts on evaluation of EH in the inner ear using MRI. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 55:809–813. https://doi.org/10.3760/cma.j.cn115330-20200327-00248

    Article  Google Scholar 

  9. Deng W, Lin X, Su Y, Cai Y, Zhong J, Ou Y (2022) Comparison between 3D-FLAIR and 3D-real IR MRI sequences with visual classification method in the imaging of endolymphatic hydrops in Meniere’s disease. Am J Otolaryngol 43:103557. https://doi.org/10.1016/j.amjoto.2022.103557

    Article  PubMed  Google Scholar 

  10. Baráth K, Schuknecht B, Naldi AM, Schrepfer T, Bockisch CJ, Hegemann SC (2014) Detection and grading of endolymphatic hydrops in Menière disease using MR imaging. AJNR Am J Neuroradiol 35:1387–1392. https://doi.org/10.3174/ajnr.A3856

    Article  PubMed  PubMed Central  Google Scholar 

  11. Han Z, Qiu X, Huang Y, Sun Q, Ding H, Xie J, Guo J, Yang Y, Liu Y, Gong S, Zhao P, Wang Z (2023) Correlation between grading methods of the cochlear endolymphatic hydrops and hearing loss in Meniere’s disease using three-dimensional real inversion recovery sequences. Acta Otolaryngol 143:370–375. https://doi.org/10.1080/00016489.2023.2209134

    Article  PubMed  Google Scholar 

  12. Nakashima T, Naganawa S, Pyykko I, Gibson WP, Sone M, Nakata S, Teranishi M (2009) Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol. https://doi.org/10.1080/00016480902729827

    Article  PubMed  Google Scholar 

  13. Gürkov R, Flatz W, Louza J, Strupp M, Krause E (2011) In vivo visualization of endolyphatic hydrops in patients with Meniere’s disease: correlation with audiovestibular function. Eur Arch Otorhinolaryngol 268:1743–1748. https://doi.org/10.1007/s00405-011-1573-3

    Article  PubMed  Google Scholar 

  14. Yang S, Zhu H, Zhu B, Wang H, Chen Z, Wu Y, Chen B, Shi H, Li Y, Zou J, Yin S (2018) Correlations between the degree of endolymphatic hydrops and symptoms and audiological test results in patients with Menière’s disease: a reevaluation. Otol Neurotol 39:351–356. https://doi.org/10.1097/MAO.0000000000001675

    Article  PubMed  Google Scholar 

  15. Fang ZM, Chen X, Gu X, Liu Y, Zhang R, Cao DR, He HG (2012) A new magnetic resonance imaging scoring system for perilymphatic space appearance after intratympanic gadolinium injection, and its clinical application. J Laryngol Otol 126:454–459. https://doi.org/10.1017/S0022215112000060

    Article  PubMed  Google Scholar 

  16. Liu F, Huang W, Chen Q, Gao Z (2015) Comparison of noninvasive evaluation of endolymphatic space in healthy volunteers in different age groups using magnetic resonance imaging. Acta Otolaryngol 135:416–421. https://doi.org/10.3109/00016489.2014.986760

    Article  PubMed  Google Scholar 

  17. Bernaerts A, Vanspauwen R, Blaivie C, van Dinther J, Zarowski A, Wuyts FL, Vanden Bossche S, Offeciers E, Casselman JW, De Foer B (2019) The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Menière’s disease on MRI. Neuroradiology 61:421–429. https://doi.org/10.1007/s00234-019-02155-7

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, Newman-Toker DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A (2015) Diagnostic criteria for Menière’s disease. J Vestib Res 25:1–7. https://doi.org/10.3233/VES-150549

    Article  PubMed  Google Scholar 

  19. Yang CJ, Yoshida T, Sugimoto S, Teranishi M, Kobayashi M, Nishio N, Naganawa S, Sone M (2021) Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss. Acta Otolaryngol 141:5–9. https://doi.org/10.1080/00016489.2020.1827159

    Article  PubMed  Google Scholar 

  20. Niu Y, Chen W, Lin M, Sha Y (2022) Development and characteristics of hearing loss with the progression of endolymphatic hydrops. Ear Nose Throat J. https://doi.org/10.1177/01455613221101088

    Article  PubMed  Google Scholar 

  21. Sun Q, Jiang G, Xiong G, Sun W, Wen W, Wei F (2021) Quantification of endolymphatic hydrops and its correlation with Meniere’s disease clinical features. Clin Otolaryngol 46:1354–1361. https://doi.org/10.1111/coa.13847

    Article  PubMed  Google Scholar 

  22. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière’s disease (1995) American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg 113:181–185. https://doi.org/10.1016/S0194-5998(95)70102-8

    Article  Google Scholar 

  23. Liu F, Huang W, Meng X, Wang Z, Liu X, Chen Q (2012) Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere’s disease and endolymphatic space in healthy volunteers using magnetic resonance imaging. Acta Otolaryngol 132:234–240. https://doi.org/10.3109/00016489.2011.637232

    Article  CAS  PubMed  Google Scholar 

  24. Sone M, Yoshida T, Sugimoto S, Kobayashi M, Teranishi M, Naganawa S (2022) Pathological significance and classification of endolymphatic hydrops in otological disorders. Nagoya J Med Sci 84:497–505. https://doi.org/10.18999/nagjms.84.3.497

    Article  PubMed  PubMed Central  Google Scholar 

  25. Han SC, Kim YS, Kim Y, Lee SY, Song JJ, Choi BY, Kim JS, Bae YJ, Koo JW (2022) Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere’s disease. Front Neurol 13:937703. https://doi.org/10.3389/fneur.2022.937703

    Article  PubMed  PubMed Central  Google Scholar 

  26. Wnuk E, Lachowska M, Jasińska-Nowacka A, Maj E, Rowiński O, Niemczyk K (2022) Detailed insight into magnetic resonance assessment of Ménière’s disease—description of methodology and imaging findings in a case series. Pol J Radiol 87:e354–e362. https://doi.org/10.5114/pjr.2022.117971

    Article  PubMed  PubMed Central  Google Scholar 

  27. Jasińska A, Lachowska M, Wnuk E, Pierchała K, Rowiński O, Niemczyk K (2022) Correlation between magnetic resonance imaging classification of endolymphatic hydrops and clinical manifestations and audiovestibular test results in patients with definite Ménière’s disease. Auris Nasus Larynx 49:34–45. https://doi.org/10.1016/j.anl.2021.03.027

    Article  PubMed  Google Scholar 

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Acknowledgements

None.

Funding

This study was supported by the National Natural Science Foundation of China (No.61931013, No. 82171886) the Natural Science Foundation of Beijing Municipality (No.7222301), the Beijing Scholars Program (No. [2015] 160), and the Beijing key Clinical Discipline Funding (No. 2021-135).

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Author notes

  1. Zhihao Han and Yan Huang contributed equally to this study.

Authors and Affiliations

  1. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Yongan Road 95, Beijing, China

    Zhihao Han, Yan Huang, Zhenghan Yang, Zhenchang Wang & Pengfei Zhao

  2. Department of Imaging, Weihai Central Hospital, Qingdao University, Weihai, China

    Zhihao Han

  3. Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Jing Xie, Yuhe Liu & Shusheng Gong

Authors
  1. Zhihao Han
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Contributions

Conceptualization: ZH, YH, PZ. Methodology: ZH, YH, YL, SG, ZY. Data curation: ZH, YH. Writing—original draft preparation: ZH, YH. Writing—review and editing: all authors. Visualization: JX, ZW, PZ. Supervision: PZ. All authors contributed to the article and approved the submitted version.

Corresponding author

Correspondence to Pengfei Zhao.

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Ethics approval

This study adhered to the Declaration of Helsinki and ethical approval was obtained from the Ethics Committee of Beijing Friendship Hospital, Capital Medical University (No. 2022-P2-259-02). Informed consent was obtained from all patients.

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The authors declare that there are no competing interests to report.

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Han, Z., Huang, Y., Xie, J. et al. Comparative analysis of vestibular endolymphatic hydrops grading methods and hearing loss in Ménière’s disease: a retrospective MRI study using 3D-real inversion recovery sequence. Eur Arch Otorhinolaryngol (2024). https://doi.org/10.1007/s00405-024-08630-z

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