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Clinical characteristics of local allergic rhinitis sensitized to house dust mites in Asia

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Local allergic rhinitis (LAR) is characterized by a localized nasal allergic response without evidence of systemic atopy. LAR is an underdiagnosed entity and is a diagnostic and therapeutic challenge for clinicians. This study aimed to investigate the prevalence and clinical characteristics of patients with LAR to house dust mites (LAR-HDM) in Korea.

Methods

We performed a retrospective chart review of 336 adult patients with rhinitis symptoms who visited the Rhinologic Clinic at Korea University Guro Hospital from October 2019 to April 2021. Using results of the skin prick test, serologic test, and nasal provocation test, patients were classified as allergic rhinitis (AR) to HDM (AR-HDM), AR to other allergens, non-allergic rhinitis (NAR), or LAR-HDM. We excluded patients with AR to other allergens and compared the clinical characteristics of the remaining three groups. Patient demographic data were reviewed, and patients’ nasal symptoms, olfactory function, serum total IgE, and severity of accompanying rhinosinusitis were evaluated.

Results

In total, 336 patients were examined. AR-HDM was diagnosed in 138 (41.1%) patients, AR to other allergens in 36 (10.7%) patients, NAR in 21 (42.0%) patients, and LAR-HDM in 21 (6.3%) patients. The mean age of patients with LAR-HDM was significantly higher than that of patients with AR-HDM. There were no significant differences in sex, smoking history, asthma, and family history of allergic diseases between the groups. Compared to NAR patients, there were significantly more patients with LAR-HDM who had persistent nasal symptoms. The frequency of nasal itching and sneezing was significantly higher in the LAR-HDM group than in the NAR group. The olfactory function score in the LAR-HDM group was significantly worse than that in the AR-HDM group, and the Lund-Mackay score was significantly higher in the LAR-HDM group than in the other groups.

Conclusion

Clinical history and nasal symptoms are very similar in LAR-HDM and AR-HDM. Clinicians should take more care to differentiate them. LAR-HDM should also be considered in patients with persistent and severe nasal symptoms without systemic atopy.

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Data availability

The datasets used and/or analysed during the current study available from the corresponding author onreasonable request.

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Author notes

  1. Su-Jong Kim and Jee Won Moon equally contributed to this work.

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University College of Medicine, 148 Gurodong-Ro, Guro-Gu, Seoul, 08308, Republic of Korea

    Su-Jong Kim, Jee Won Moon, Yongmin Cho & Heung-Man Lee

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  1. Su-Jong Kim
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  2. Jee Won Moon
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  3. Yongmin Cho
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  4. Heung-Man Lee
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Contributions

Conceptualization: HML. Data curation: SJK, JWM, YMJ. Formal analysis HML. Writing original draft: SJK. Writing—review and editing: all authors.

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Correspondence to Heung-Man Lee.

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Kim, SJ., Moon, J.W., Cho, Y. et al. Clinical characteristics of local allergic rhinitis sensitized to house dust mites in Asia. Eur Arch Otorhinolaryngol 281, 2413–2420 (2024). https://doi.org/10.1007/s00405-023-08394-y

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  • DOI: https://doi.org/10.1007/s00405-023-08394-y

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