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The percentage of controlled chronic rhinosinusitis after treatment: a systematic review and meta-analysis

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Abstract

Purpose

Chronic rhinosinusitis (CRS) is a chronic disease with a high recurrence rate, and the aim of treating CRS is to maintain disease control. Recently, a series of CRS control instruments have been developed to assess the control levels. We pooled existing studies to evaluate the percentage of controlled CRS after treatment in patients with CRS.

Methods

A systematic literature review and meta-analysis using PubMed, Google Scholar, Scopus, and Cochrane databases was conducted to identify studies assessing CRS control. Both comprehensive assessments and self-report of CRS control were included.

Results

9 studies with 1931 patients after treatment and 295 patients before treatment were included. CRS control assessments of the 2012 European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS 2012), EPOS 2020, and Sinus Control Test (SCT) were comprehensive assessments utilized in the clinic practice. The self-report assessment included patient-reported global level of CRS control. These existing disease control instruments categorized patients into three (uncontrolled, partly controlled, and controlled) or five (not at all, a little, somewhat, very, and completely) control categories. Only 8% (95% CI 0.05–0.11) of patients with CRS stayed well controlled before treatment assessed by comprehensive assessments. About 35% (95% CI 0.22–0.49) of patients achieved well controlled after treatment when assessed by the comprehensive measures. Meanwhile, 40% (95% CI 0.28–0.52) of patients reported well controlled after treatment when using self-report.

Conclusion

About 35–40% of patients with CRS showed well controlled after treatment, which stressed the importance of identifying these undertreated patients with CRS.

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Funding

Natural Science Foundation of China (82000954), Beijing Science and Technology Nova Program (Z201100006820086), Beijing Hospitals Authority Youth Program (QML20190617), and Beijing Hospitals Authority Clinical Medicine Development of Special Funding (XMLX202136).

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Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, No. 49 Huayuan North Road, Haidian District, Beijing, 100191, People’s Republic of China

    Tianhao Huang, Jiahui Zhou, Yan Yan & Dawei Wu

  2. Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China

    Tianhao Huang

  3. Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China

    Fan Yuan

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  1. Tianhao Huang
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  2. Jiahui Zhou
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  4. Yan Yan
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Contributions

All authors have made substantial contributions to the conception, analysis, and interpretation of data in this article, approved the submitted version, and agreed to be personally accountable for our contributions and to ensure that questions related to the accuracy or integrity of any part of the work, even ones in which we are not personally involved, are appropriately investigated, resolved, and the resolution documented in the literature.

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Correspondence to Yan Yan or Dawei Wu.

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Huang, T., Zhou, J., Yuan, F. et al. The percentage of controlled chronic rhinosinusitis after treatment: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 281, 2183–2194 (2024). https://doi.org/10.1007/s00405-023-08363-5

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  • DOI: https://doi.org/10.1007/s00405-023-08363-5

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