Skip to main content

Advertisement

SpringerLink
Log in

Treatment strategy in laryngeal chondrosarcoma: a multicenter study of 43 cases

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Laryngeal chondrosarcoma is a rare tumor that mostly affects the cricoid cartilage. The aim of this study was to compare outcomes between the various treatments of this pathology as there are no official guidelines for this pathology.

Methods

A retrospective analysis of the pathology database of nine French tertiary care centers was conducted. Outcomes of patients treated by total laryngectomy were compared with those treated by more conservative approaches (endoscopic debulking, median thyrotomy, partial laryngectomy). Two Kaplan–Meier survival analyses were performed: one to assess the overall survival rate and the other to assess laryngeal preservation over time.

Results

A total of 43 patients were enrolled: 12 with total laryngectomy as the initial treatment, and 31 who initially underwent laryngeal-preserving treatment. With conservative treatment, laryngeal function was preserved in 96% and 75% of patients at 1 and 5 years, respectively. Conservative treatment did not reduce the overall survival rate.

Conclusion

These results suggest that laryngeal preservation should be considered as the initial treatment in cases of laryngeal chondrosarcoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

References

  1. Travers F (1816) A case of ossification and bony growth of the cartilages of the larynx, preventing deglutition. Med Chir Trans 7:150–153

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Thompson LDR, Gannon FH (2002) Chondrosarcoma of the larynx: a clinicopathologic study of 111 cases with a review of the literature. Am J Surg Pathol 26(7):836–851. https://doi.org/10.1097/00000478-200207000-00002

    Article  PubMed  Google Scholar 

  3. Dubal PM, Svider PF, Kanumuri VV, Patel AA, Baredes S, Eloy JA (2014) Laryngeal chondrosarcoma: a population-based analysis: laryngeal chondrosarcoma. Laryngoscope 124(8):1877–1881. https://doi.org/10.1002/lary.24618

    Article  PubMed  Google Scholar 

  4. Chin OY, Dubal PM, Sheikh AB et al (2017) Laryngeal chondrosarcoma: a systematic review of 592 cases: laryngeal chondrosarcoma. Laryngoscope 127(2):430–439. https://doi.org/10.1002/lary.26068

    Article  PubMed  Google Scholar 

  5. O’Neal LN, Ackerman LV et al (1952) Chondrosarcoma of bone. Cancer 5:551–577

    Article  PubMed  Google Scholar 

  6. Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading. Cancer 40(2):818–831. https://doi.org/10.1002/1097-0142(197708)40:2%3c818::AID-CNCR2820400234%3e3.0.CO;2-B

    Article  CAS  PubMed  Google Scholar 

  7. Casiraghi O, Martinez-Madrigal F, Pineda-Daboin K, Mamelle G, Resta L, Luna MA (2004) Chondroid tumors of the larynx: a clinicopathologic study of 19 cases, including two dedifferentiated chondrosarcomas. Ann Diagn Pathol 8(4):189–197. https://doi.org/10.1053/j.anndiagpath.2004.04.001

    Article  PubMed  Google Scholar 

  8. Ferlito A, Devaney KO, Mäkitie AA (2019) Differing characteristics of cartilaginous lesions of the larynx. Eur Arch Otorhinolaryngol 276(10):2635–2647. https://doi.org/10.1007/s00405-019-05563-w

    Article  PubMed  PubMed Central  Google Scholar 

  9. Tallegas M, Miquelestorena-Standley É, Labit-Bouvier C et al (2019) IDH mutation status in a series of 88 head and neck chondrosarcomas: different profile between tumors of the skull base and tumors involving the facial skeleton and the laryngotracheal tract. Hum Pathol 84:183–191. https://doi.org/10.1016/j.humpath.2018.09.015

    Article  CAS  PubMed  Google Scholar 

  10. Piazza C, Paderno A, Nicolai P (2017) Conservative surgery for laryngeal chondrosarcoma: a review of the most recently proposed approaches. Curr Opin Otolaryngol Head Neck Surg 25(2):93–100. https://doi.org/10.1097/MOO.0000000000000337

    Article  PubMed  Google Scholar 

  11. Zeitels SM, Baird BJ (2022) Surgical treatment strategies for laryngeal chondrosarcomas: a single institution investigation. Laryngoscope 132(1):169–176. https://doi.org/10.1002/lary.29762

    Article  PubMed  Google Scholar 

  12. Pelliccia P, Pero MMD, Mercier G, Iannetti G, Makeieff M (2014) Transoral endoscopic resection of low-grade, cricoid chondrosarcoma: endoscopic management of a series of seven patients with low-grade cricoid chondrosarcoma. Ann Surg Oncol 21(8):2767–2772. https://doi.org/10.1245/s10434-014-3668-8

    Article  PubMed  Google Scholar 

  13. Oestreicher-Kedem Y, Dray TG, Damrose EJ (2009) Endoscopic resection of low grade, subglottic chondrosarcoma. J Laryngol Otol 123(12):1364–1366. https://doi.org/10.1017/S0022215109990284

    Article  CAS  PubMed  Google Scholar 

  14. Merrot O, Gleizal A, Poupart M, Pignat JC (2009) Cartilaginous tumors of the larynx: endoscopic laser management using YAG/KTP. Head Neck 31(2):145–152. https://doi.org/10.1002/hed.20932

    Article  PubMed  Google Scholar 

  15. Aygenc E, Dere H, Ozdem C (2003) Endolaryngeal resection of laryngeal chondrosarcoma. Eur Arch Otorhinolaryngol 260(10):555–557. https://doi.org/10.1007/s00405-003-0637-4

    Article  PubMed  Google Scholar 

  16. Cohen JT, Koufman JA et al (2003) Hemicricoidectomy as the primary diagnosis and treatment for cricoid chondrosarcomas. Laryngoscope 113:1817–1819

    Article  PubMed  Google Scholar 

  17. Damiani V, Crosetti E, Rizzotto G, Camaioni A, Succo G (2014) Well and intermediate differentiated laryngeal chondrosarcoma: toward conservative surgery? Eur Arch Otorhinolaryngol 271(2):337–344. https://doi.org/10.1007/s00405-013-2656-0

    Article  PubMed  Google Scholar 

  18. Gripp S, Pape H, Schmitt G (1998) Chondrosarcoma of the larynx, the role of radiotherapy revisited, a case report and review of the literature. Cancer 82:108–114. https://doi.org/10.1002/(SICI)1097-0142(19980101)82:13.0.CO;2-6

    Article  CAS  PubMed  Google Scholar 

  19. Dailiana T, Nomikos P, Kapranos N, Papaioannou G, Kelekis DA et al (2002) Chondrosarcoma of the larynx: treatment with radiotherapy. Skelet Radiol 31(9):547–549. https://doi.org/10.1007/s00256-002-0527-7

    Article  CAS  Google Scholar 

  20. Talati VM, Urban MJ, Patel TR et al (2022) Laryngeal chondrosarcoma characteristics and survival analysis in the national cancer database. Otolaryngol Neck Surg 166(1):101–108. https://doi.org/10.1177/01945998211004578

    Article  Google Scholar 

  21. Lewis JE, Olsen KD, Inwards CY (1997) Cartilaginous tumors of the larynx: clinicopathologic review of 47 cases. Ann Otol Rhinol Laryngol 106(2):94–100. https://doi.org/10.1177/000348949710600202

    Article  CAS  PubMed  Google Scholar 

  22. Rinaldo A, Howard DJ (2000) Laryngeal chondrosarcoma: a 24-year experience at the Royal National Throat, Nose and Ear Hospital. Acta Otolaryngol (Stockh) 120(6):680–688. https://doi.org/10.1080/000164800750000199

    Article  CAS  PubMed  Google Scholar 

  23. Piazza C, Del Bon F, Grazioli P et al (2014) Organ preservation surgery for low- and intermediate-grade laryngeal chondrosarcomas: analysis of 16 cases: conservative surgery for laryngeal chondrosarcoma. Laryngoscope 124(4):907–912. https://doi.org/10.1002/lary.24416

    Article  PubMed  Google Scholar 

  24. Bathala S, Berry S, Evans RA, Brodie S, Altaan O (2008) Chondrosarcoma of larynx: review of literature and clinical experience. J Laryngol Otol 122(10):1127–1129. https://doi.org/10.1017/S002221510700076X

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

This study was not supported by any funding.

Author information

Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Tours, 2 Boulevard Tonnellé, 37000, Tours, France

    Marianne Schleich & Sylvain Moriniere

  2. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Angers, Angers, France

    Laurent Laccourreye

  3. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Brest, Brest, France

    Remi Marianowski

  4. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Poitiers, Poitiers, France

    Xavier Dufour

  5. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Caen, Caen, France

    Emmanuel Babin

  6. Department of Otolaryngology-Head and Neck Surgery, François Baclesse Center, Caen, France

    Vianney Bastit

  7. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Rouen, Rouen, France

    Jean Paul Marie

  8. Department of Pathology, European Hospital of Georges Pompidou, Paris, France

    Cécile Badoual

  9. Department of Otolaryngology-Head and Neck Surgery, Croix Rousse University Hospital, Lyons, France

    Pierre Philouze

  10. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Nantes, Nantes, France

    Florent Espitalier

  11. Department of Pathology, University Hospital of Tours, Tours, France

    Gonzague Du Bouexic De Pinieux

Authors
  1. Marianne Schleich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Laurent Laccourreye
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Remi Marianowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xavier Dufour
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Emmanuel Babin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Vianney Bastit
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jean Paul Marie
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Cécile Badoual
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Pierre Philouze
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Florent Espitalier
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Gonzague Du Bouexic De Pinieux
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Sylvain Moriniere
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Study conception, material preparation, data collection and analysis were performed by MS and SM. The first draft of the manuscript was written by MS and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Marianne Schleich.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study (retrospective study) formal consent is not required. And this study was approved by the committee in human research of Tours (no. 2021003).

Informed consent

For this type of study (retrospective study) formal consent is not required.

Consent for publication

For this type of study (retrospective study) consent for publication is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schleich, M., Laccourreye, L., Marianowski, R. et al. Treatment strategy in laryngeal chondrosarcoma: a multicenter study of 43 cases. Eur Arch Otorhinolaryngol 281, 883–890 (2024). https://doi.org/10.1007/s00405-023-08248-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-023-08248-7

Keywords

Search

Navigation