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Neoadjuvant chemotherapy for organ preservation in sinonasal squamous cell carcinoma

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

In this study, we aimed to evaluate the role of induction chemotherapy (IC) in the treatment of locoregionally advanced sinonasal squamous cell carcinoma (SNSCC).

Methods

130 patients who accepted IC between 2010 and 2022 were retrospectively reviewed. After IC, all the patients underwent chemoradiotherapy (CRT)/ radiotherapy (RT) or CRT/RT followed by surgery. We investigated the objective response to IC, the optimal treatment strategy, organ preservation, and long-term survival.

Results

 Eighty-seven patients (66.9%) achieved a partial response after IC. 86% (27/43) of the patients who did not respond to the IC still presented a sensitive response to radiotherapy (χ2 = 9.26, p = 0.005). Patients who respond to IC could benefit from CRT/RT followed by surgery over other treatment modalities. The 3-year overall survival (OS), progression-free survival (PFS), locoregional-free survival (LRFS), and distant metastasis-free survival (DMFS) rates of 61.2%, 51.3%, 52.1%, 58.1% for the IC response group were significantly superior to those of 37.3% (HR = 0.58, 95% CI 0.34–1.01, p = 0.030), 33.5% (HR = 0.49, 95% CI 0.30–0.82, p = 0.002), 35.9% (HR = 0.54, 95% CI 0.32–0.91, p = 0.009), 36.1% (HR = 0.60, 95% CI 0.35–1.03, p = 0.040) for the IC non-response group. Patients who responded to IC had a high rate of organ preservation compared with patients who did not respond to IC (90.8% vs. 74.4%, χ2 = 6.19, p = 0.013).

Conclusions

The results demonstrated a response rate to IC in patients with advanced SNSCC; furthermore, the response to IC indicated better survival. Patients who responded to IC had a high rate of organ preservation.

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Author notes

  1. Tian Wang, Yi Li have contributed equally to this work and are the co-first authors.

Authors and Affiliations

  1. Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Tian Wang, Li Wang, Jie Wang & Xinmao Song

  2. Department of Oncology, 920th Hospital of Joint Logistics Support Force, 212 Daguan Road, Kunming, 650032, China

    Yi Li

  3. Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Keqing Zhao

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  1. Tian Wang
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  2. Yi Li
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  3. Li Wang
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  4. Jie Wang
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Contributions

TW: Study concept and design; acquisition of data; analysis and interpretation of data; writing–initial draft. YL: Study concept and design, editing draft, technical support. LW: Acquisition of data. JW: Acquisition of data. KZ: Manuscript revision and study supervision. XS: Study concept and design; acquisition of data; analysis and interpretation of data; editing draft; statistical analysis; and study supervision.

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Correspondence to Keqing Zhao or Xinmao Song.

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Wang, T., Li, Y., Wang, L. et al. Neoadjuvant chemotherapy for organ preservation in sinonasal squamous cell carcinoma. Eur Arch Otorhinolaryngol 281, 775–784 (2024). https://doi.org/10.1007/s00405-023-08223-2

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  • DOI: https://doi.org/10.1007/s00405-023-08223-2

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