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Systemic inflammation response index predicts the postoperative recurrence of chronic rhinosinusitis with nasal polyps: a retrospective study in the Chinese population

  • Rhinology
  • Published:
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Abstract

Purpose

Endoscopic sinus surgery (ESS) is now frequently used to treat chronic sinusitis with nasal polyps (CRSwNP), but postoperative recurrence plagues many patients. We aimed to assess the value of the systemic inflammation response index (SIRI) and the systemic immune-inflammatory index (SII) for the prediction of postoperative recurrence in patients with CRSwNP.

Methods

A total of 143 patients with CRSwNP and 76 age- and sex-matched healthy subjects were enrolled. Patients were divided into the recurrence group and the non-recurrence group according to the recurrence of CRSwNP. Univariate and multivariate analyses showed independent risk factors for the recurrence. A receiver operating characteristic curve analysis was conducted to assess the predictive accuracy of the variables and determine the optimal cut-off values. Finally, a survival analysis was conducted.

Results

Univariate analysis revealed that age, sex, CRP, EOS, SIRI, SII, NLR, ELR, and Lund–Mackay CT scores were significant predictors of the recurrence of CRSwNP. Multivariate analysis confirmed that SIRI (OR = 1.310, p < 0.001) and Lund–Mackay CT scores (OR = 1.396, p < 0.001) were independent predictors. SIRI (AUC = 0.761, 95% CI: 0.685–0.836) had a certain value in predicting the recurrence of CRSwNP.

Conclusion

SIRI is a potential predictive marker of the postoperative recurrence of CRSwNP.

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Availability of data and materials

All data generated or analyzed during this study are included in this published article.

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Acknowledgements

YQY and JZ are co-first authors. The authors thank Zongchi Liu, Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, for his participation in the study design and writing assistance.

Funding

This study was funded by the Jiangsu Science and Technology Plan Project (BE2019670) and Suzhou people's livelihood science and technology project (SYS2020115).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215000, Jiangsu, China

    Yuqing Yang, Mengyu Zhang, Yihong Wang, Fuwei Cheng & Manyi Li

  2. Center for Health Management, The First Affiliated Hospital, Soochow University, Suzhou, China

    Jing Zhu

  3. Department of Quality Management, The First Affiliated Hospital, Soochow University, Suzhou, China

    Wenxia Ma

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  1. Yuqing Yang
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Contributions

YQY planned the study. YQY, JZ, and WXM collected and analyzed data. YQY wrote the article. MYZ, JZ, YHW, FWC, and MYL revised the manuscript and polished the language. All authors read and approved the final submitted paper.

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Correspondence to Manyi Li.

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The authors have no competing interests to declare that are relevant to the content of this article.

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Approval was obtained from the scientific committee of the First Affiliated Hospital of Soochow University (Protocol number: 2023/087). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Yang, Y., Zhu, J., Zhang, M. et al. Systemic inflammation response index predicts the postoperative recurrence of chronic rhinosinusitis with nasal polyps: a retrospective study in the Chinese population. Eur Arch Otorhinolaryngol 281, 207–217 (2024). https://doi.org/10.1007/s00405-023-08182-8

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