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Causal relationship between gut microbiota and otitis media: a two-sample Mendelian randomized study

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Data availability

The datasets analyzed are publicly available summary statistics in this study.

References

  1. Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science (New York, NY) 336(6086):1268–1273. https://doi.org/10.1126/science.1223490

    Article  CAS  Google Scholar 

  2. Iacob S, Iacob DG, Luminos LM (2018) Intestinal microbiota as a host defense mechanism to infectious threats. Front Microbiol 9:3328. https://doi.org/10.3389/fmicb.2018.03328

    Article  PubMed  Google Scholar 

  3. Skrivankova VW, Richmond RC, Woolf BAR et al (2021) Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA 326(16):1614–1621. https://doi.org/10.1001/jama.2021.18236

    Article  PubMed  Google Scholar 

  4. Rosch JW, Iverson AR, Humann J et al (2014) A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO Mol Med 6(1):141–154. https://doi.org/10.1002/emmm.201202150

    Article  CAS  PubMed  Google Scholar 

  5. Xie Y, Sun J, Wei L et al (2021) Altered gut microbiota correlate with different immune responses to HAART in HIV-infected individuals. BMC Microbiol 21(1):11. https://doi.org/10.1186/s12866-020-02074-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank the MiBioGen and Fingen consortiums for providing summary statistics data for the analyses.

Funding

We are very grateful for the support of the for the funding support of Xiangyang Science and Technology Bureau, China (2021ZD15).

Author information

Author notes

  1. Qiuyang Wang, Lisha He and Huazhang Tan: Equal first authors.

Authors and Affiliations

  1. Department of ENT, First Affiliated Hospital of Soochow University, No.188 Shizi Street, Suzhou, 215000, Jiangsu, China

    Qiuyang Wang & Jisheng Liu

  2. Department of Otolaryngology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei, China

    Qiuyang Wang & Huazhang Tan

  3. Department of Evidence-Based Medicine Center, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, 15 Jiefang Road, Fancheng District, Xiangyang, 441000, China

    Guoxin Huang

  4. School of Public Health and Management, Hubei University of Medicine, Shiyan, Hubei, China

    Lisha He & Guoxin Huang

  5. Department of Teaching Office, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei, China

    Lisha He

Authors
  1. Qiuyang Wang
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  2. Lisha He
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  3. Huazhang Tan
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  4. Guoxin Huang
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  5. Jisheng Liu
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Contributions

J.L, G.H, and Q.W designed the study. L.H and Q.W contributed equally to this work L.H and H.T analyzed and interpreted the data. G.H is the guarantor of this work. Q.W and L.H contribute equally to the article. All authors revised the paper critically for intellectual content and approved the final version. All authors agree to be accountable for the work and to ensure that any questions relating to the accuracy and integrity of the paper are investigated and properly resolved.

Corresponding authors

Correspondence to Guoxin Huang or Jisheng Liu.

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All studies had been approved by a relevant ethical review board and participants had given informed consent.

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Wang, Q., He, L., Tan, H. et al. Causal relationship between gut microbiota and otitis media: a two-sample Mendelian randomized study. Eur Arch Otorhinolaryngol 280, 4715–4717 (2023). https://doi.org/10.1007/s00405-023-08102-w

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  • DOI: https://doi.org/10.1007/s00405-023-08102-w

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