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The implications of concomitant mucosal inflammation on clinical manifestations and outcomes of sinonasal inverted papilloma

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

This study examines the impact of concomitant mucosal inflammation on clinical manifestations and long-term outcomes of Inverted Papilloma (IP).

Methods

This retrospective cohort study was conducted in five tertiary medical centers. The included patients underwent an attachment-oriented surgical resection for IP with a minimum follow-up of 3 years.

Results

Of 185 patients with IP, 65 patients (35.1%) had synchronous mucosal inflammation with polypoid changes. The mean age was 56.7 years, and 69% were males. Most tumors originated from the maxillary sinus. Age, gender, Krouse stage, and tumor attachment site did not differ between the mucosal inflammation and IP-only groups. IP recurrence rate was twofold in the patients with mucosal inflammation (15.4% vs. 7.5%, p = 0.092). However, the difference was not significant, with a similar median time to recurrence between the two groups [15.5 (3–36) months vs. 16(6–96) months, p = 0.712]. In revision cases, IP recurred only in patients with mucosal inflammation (19% vs. 0%, p = 0.07). This group had a significantly worse 5-years recurrence-free survival than revision cases without mucosal inflammation (80.6% vs. 100%, p = 0.04).

Conclusions

IP in the setting of mucosal inflammation might be associated with a higher recurrence rate, predominantly after revision surgery. Otolaryngologists should consider this during these patients’ diagnosis, surgical planning, and follow-up.

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Availability of data and materials

The data that support the results of this study are available from the corresponding author upon reasonable request.

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Author information

Author notes

  1. Noa Rozendorn and Arkadi Yakirevitch share senior authorship.

Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Sheba Medical Center, Tel-Hashomer, 52621, Ramat-Gan, Israel

    Noa Rozendorn, Arkadi Yakirevitch & Eran Glikson

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Arkadi Yakirevitch, Eran Glikson, Amit Ritter & Ethan Soudry

  3. ARM Center of Otolaryngology-Head and Neck Surgery, Assuta Medical Center, Tel Aviv, Israel

    Roee Landsberg & Shay Schneider

  4. Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel

    Amit Ritter & Ethan Soudry

  5. Department of Otorhinolaryngology, Ospedale San Giuseppe IRCCS Multimedica, Milan, Italy

    Francesco Mozzanica

  6. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Francesco Mozzanica

Authors
  1. Noa Rozendorn
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  2. Arkadi Yakirevitch
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  3. Eran Glikson
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  4. Roee Landsberg
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  5. Amit Ritter
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  6. Francesco Mozzanica
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  7. Shay Schneider
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  8. Ethan Soudry
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Contributions

NR: acquisition of data, analysis of data, drafting of article and/or critical revision, and final approval of the manuscript. AY: conception and design of the study, drafting of article and/or critical revision, and final approval of the manuscript. EG: acquisition of data and final approval of the manuscript. RL: drafting of article and/or critical revision, and final approval of the manuscript. AR: analysis of data, final approval of the manuscript. FM: acquisition of data and final approval of the manuscript. SS: acquisition of data and final approval of the manuscript. ES: conception and design of the study, drafting of article and/or critical revision, and final approval of the manuscript.

Corresponding author

Correspondence to Noa Rozendorn.

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Rozendorn, N., Yakirevitch, A., Glikson, E. et al. The implications of concomitant mucosal inflammation on clinical manifestations and outcomes of sinonasal inverted papilloma. Eur Arch Otorhinolaryngol 280, 4963–4968 (2023). https://doi.org/10.1007/s00405-023-08088-5

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  • DOI: https://doi.org/10.1007/s00405-023-08088-5

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