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Epidemiological and clinical characteristics of synchronous lung metastasis in major salivary gland mucoepidermoid carcinoma

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Abstract

Objectives

To analyze the risk factors for synchronous lung metastases (LM) in patients with major salivary gland mucoepidermoid carcinoma (MaSG-MEC).

Methods

MaSG-MEC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. Descriptive statistics were used to examine the baseline characteristics of the patients. We examined the association between risk factors and synchronous LM using Chi-squared tests. The primary study outcomes were overall survival (OS) and cancer-specific survival (CSS). Kaplan–Meier survival curves were compared using the log-rank test. Hazard analysis was conducted using the Cox proportional hazards model. Results: A total of 701 patients were analyzed, which including 8 patients (1.1%) with synchronous LM, and 693 patients without synchronous LM (98.9%). Lower T or N classification, and highly differentiated disease were associated with a significantly lower risk of LM and multivariate logistic regression analysis showed that lower T classification were associated with a significantly lower risk of LM (P < 0.05, respectively). Elderly Caucasian male patients with poorly differentiated disease, multiple sites of metastases and no surgical therapy to primary tumor were more likely to reduce life expectancy.

Conclusion

By analyzing data from a large cohort, lower T or N classification and highly differentiated disease were associated with a significantly lower risk of LM. Elderly Caucasian male patients with poorly differentiated disease, multiple sites of metastases and no surgical therapy to primary tumor were more likely to reduce life expectancy. More accurate assessments of LM will be imperative for early diagnosis and treatment in patients who harbored with higher T or N classification and poorly differentiated disease.

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Data availability

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

The study was funded by the Clinical research on health industry of Shanghai Health Commission (grant numbers: 20214Y0025). The study was funded by the Clinical research of Shanghai Pudong District Health Commission (grant numbers: PW2022A-41).

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Authors and Affiliations

  1. Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, 201321, China

    Yujiao Li & Chaosu Hu

  2. Shanghai Key Laboratory of Radiation Oncology (20dz2261000), Shanghai, 201321, China

    Yujiao Li & Chaosu Hu

  3. Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, 201321, China

    Yujiao Li & Chaosu Hu

  4. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China

    Yujiao Li & Chaosu Hu

  5. Department of Oncology, Shanghai Medical College, Shanghai, China

    Yujiao Li & Chaosu Hu

Authors
  1. Yujiao Li
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  2. Chaosu Hu
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Correspondence to Chaosu Hu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of XXX Ethics committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The experimental protocols were also approved by XXX Ethics committee. Written informed consent was obtained from all individual participants included in the study.

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Li, Y., Hu, C. Epidemiological and clinical characteristics of synchronous lung metastasis in major salivary gland mucoepidermoid carcinoma. Eur Arch Otorhinolaryngol 280, 3835–3841 (2023). https://doi.org/10.1007/s00405-023-07963-5

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  • DOI: https://doi.org/10.1007/s00405-023-07963-5

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