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Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer

  • Head and Neck
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

A Correction to this article was published on 08 June 2023

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Abstract

Purpose

This study sought to investigate the prognostic value of the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and prognostic nutritional index (PNI) in patients with head and neck cancer.

Methods

The data of 310 patients with head and neck cancer who were referred to the Radiation Oncology Clinic of Sivas Cumhuriyet University Faculty of Medicine (n = 271, 87%) and to S.B.U. Dr. Abdurrahman Yurtaslan Ankara Oncology Health Practice and Research Centre (n = 39, 13%) between January 2009 and March 2020 were retrospectively analysed. At the time of diagnosis, patients’ neutrophil, lymphocyte, monocyte, platelet and albumin levels were used to calculate their SII, SIRI and PNI indices.

Results

Multivariate analysis found the after variables to be independent prognostic factors for overall survival (OS): SII [hazard ratio (HR) 1.71, 95% confidence interval (CI) 1.18–2.47; p = 0.002] and PNI (HR 0.66, 95% CI 0.43–0.97; p = 0.038), stage (HR 2.11, 95% CI 1.07–4.16; p = 0.030), fraction technique (HR 0.49, 95% CI 0.28–0.85; p = 0.011) and age (HR 2.51, 95% CI 1.77–3.57; p = 0.001).The following variables were found to be independent prognostic factors for disease-free survival (DFS) in multivariate analysis: SII (HR 2.16, 95% CI 1.22–3.83; p = 0.008), fractionation technique (HR 0.17, 95% CI 0.004–0.64; p = 0.017) and age (HR 2.11, 95% CI 1.13–3.93; p = 0.019).

Conclusion

This study found a high SII to be an independent poor prognostic factor for both OS and DFS, while a low PNI was found to be an independent poor prognostic factor only for OS.

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Data availability

Data availability of datasets created and analyzed during the current study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Radiation Oncology, Medical Faculty of Saglik Bilimleri University, Dr. Abdurrahman Yurtarslan Oncology Research and Training Hospital, Ankara, Turkey

    Ebru Atasever Akkas

  2. Department of Radiation Oncology, Medical Faculty of Cumhuriyet University, Sivas, Turkey

    Eda Erdis & Birsen Yucel

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  1. Ebru Atasever Akkas
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Contributions

Conceptualization: EAA, BY; formal analysis and investigation: BY, EAA, EE; writing—original draft preparation: BY, EAA; writing—review and editing: BY, EAA.

Corresponding author

Correspondence to Ebru Atasever Akkas.

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Conflict of interest

The authors have no funding, financial relationships, or conflict of interest to disclose.

Ethics approval

The study was approved by the Institutional Review Board of Dr. Abdurrahman Yurtarslan Oncology Health Practice and Research Center (Ethics committee approval waived off as this is a retrospective study decision no:2020-11/87 Date:11.11.2020) The principles of the Declaration of Helsinki conducted this study.

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Atasever Akkas, E., Erdis, E. & Yucel, B. Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer. Eur Arch Otorhinolaryngol 280, 3821–3830 (2023). https://doi.org/10.1007/s00405-023-07954-6

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