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Comparison of prognostic and treatment between T1a and T1b glottic cancer: a propensity score-matched SEER database analysis

  • Laryngology
  • Published:
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Abstract

Purpose

The prognoses of T1a and T1b glottic cancers are still controversial. This study aimed to compare the prognosis difference between the two groups based on the population-based Surveillance, Epidemiology, and End Results database (SEER).

Methods

Data for patients with T1a or T1b glottic cancers were extracted from the SEER database. The bias between T1a and T1b glottic cancers was minimized with Propensity Score Matching (PSM), and disease-specific survival (DSS) was analyzed using the Kaplan–Meier method, log-rank test, and Cox proportional hazards models.

Results

A total of 5,272 patients were extracted from the database, including 847 patients with T1b glottic cancer that were 1:1 propensity score-matched with patients with T1a glottic cancer. After propensity score-matching, there was no statistical difference in disease-specific survival between T1a and T1b patients, whilst survival was impaired by old age. However, on the multivariate analysis, the T1a stage was associated with improved DSS compared with the T1b stage.

Conclusion

Our analysis showed that T1a glottic cancers didn’t have a significantly better prognosis compared with T1b after PSM. However, the DSS of T1a patients is superior to that of T1b patients in multivariate analysis.

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Data availability

The data in this study from the SEER database, which was open access for research purposes. The authors were permitted to access the data at the website (http://www.seer.cancer.gov) with the identifier, 12020-Nov2021.

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Author information

Author notes

  1. Lucheng Fang and Aikebaier Tuohuti have contributed equally to this work.

Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China

    Lucheng Fang, Aikebaier Tuohuti & Xiong Chen

  2. Sleep Medicine Centre, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

    Lucheng Fang, Aikebaier Tuohuti & Xiong Chen

  3. First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

    Licai Shi

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  1. Lucheng Fang
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Correspondence to Xiong Chen.

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Fang, L., Tuohuti, A., Shi, L. et al. Comparison of prognostic and treatment between T1a and T1b glottic cancer: a propensity score-matched SEER database analysis. Eur Arch Otorhinolaryngol 280, 3313–3322 (2023). https://doi.org/10.1007/s00405-023-07953-7

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  • DOI: https://doi.org/10.1007/s00405-023-07953-7

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