Abstract
Purpose
To investigate the factors influencing the volume of the olfactory bulb (OB) in patients with post-viral olfactory dysfunction (PVOD).
Methods
We collected 92 olfactory bulb volumes from patients with PVOD who underwent a sinus computed tomographic and magnetic resonance imaging (MRI) scan of the head and collected clinical information including gender, age, disease course, minimal cross-sectional area, nasal airway resistance, and olfactory function. OB volume was measured in MRI and the scans were evaluated according to the Lund-Mackay (LM) scoring system.
Results
Male patients with PVOD had a larger OB volume (β = 0.284, P < 0.05). OB volume was smaller in patients with a longer course of olfactory dysfunction (β = − 0.254, P < 0.05). According to the LM scoring system, patients with a higher anterior ethmoidal sinus score had smaller OB volume (β = − 0.476, P < 0.05).
Conclusions
The study revealed that gender, disease course, and the score of anterior ethmoidal sinusitis can affect the OB volume in patients with PVOD.
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Data availability
The anonymised data that support the findings of this study are available from the corresponding author upon reasonable request.
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Acknowledgements
We thank the participants of the study.
Funding
This study was supported by grants from the National Key R&D Program of China (2019YFE0116000, 2020YFC2005200).
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Hu, C., Gao, Y., Feng, Y. et al. Assessment of factors influencing the olfactory bulb volume in patients with post-viral olfactory dysfunction. Eur Arch Otorhinolaryngol 280, 3737–3743 (2023). https://doi.org/10.1007/s00405-023-07932-y
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DOI: https://doi.org/10.1007/s00405-023-07932-y