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Beyond the boundaries of compartmental hemiglossectomy: a proposal for an anatomically based classification of surgical approaches to advanced oral tongue squamous cell carcinoma

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Abstract

Introduction

In the last decade, compartmental surgery (CTS) has been the surgical approach of choice for advanced tumors of the tongue and oral floor.

Methods

Advanced tumors (cT3–T4) oral tongue squamous cell carcinoma (OTSCC) may extend beyond the lingual septum and involve the contralateral hemitongue, developing along the intrinsic transverse muscle. The disease may then involve the genioglossus muscle and, more laterally, the hyoglossus muscle.

Results

The surgical approach to the contralateral tongue must be guided by anatomic and anatomopathological principles to achieve a safe oncological resection based on the principles of CTS.

Conclusion

We propose a schematic classification of glossectomies that extend to the contralateral hemitongue based on the anatomy and pathways of tumor spread.

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Data availability

Data available within the article or its supplementary materials.

References

  1. Ng JH, Iyer NG, Tan MH, Edgren G (2017) Changing epidemiology of oral squamous cell carcinoma of the tongue: a global study. Head Neck 39(2):297–304. https://doi.org/10.1002/hed.24589

    Article  PubMed  Google Scholar 

  2. Calabrese L, Giugliano G, Bruschini R et al (2009) Compartmental surgery in tongue tumours: description of a new surgical technique. Acta Otorhinolaryngol Ital 29(5):259–264

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Calabrese L, Tagliabue M, Maffini F, Massaro MA, Santoro L (2013) From wide excision to a compartmental approach in tongue tumors: what is going on? Curr Opin Otolaryngol Head Neck Surg 21(2):112–117. https://doi.org/10.1097/MOO.0b013e32835e28d2

    Article  PubMed  Google Scholar 

  4. Tagliabue M, Gandini S, Maffini F et al (2019) The role of the T-N tract in advanced stage tongue cancer. Head Neck 41(8):2756–2767. https://doi.org/10.1002/hed.25761

    Article  PubMed  Google Scholar 

  5. Grammatica A, Piazza C, Ferrari M et al (2021) Step-by-step cadaver dissection and surgical technique for compartmental tongue and floor of mouth resection. Front Oncol 11:613945. https://doi.org/10.3389/fonc.2021.613945. (Published 2021 Apr 23)

    Article  PubMed  PubMed Central  Google Scholar 

  6. Calabrese L, Bruschini R, Giugliano G et al (2011) Compartmental tongue surgery: long term oncologic results in the treatment of tongue cancer. Oral Oncol 47(3):174–179. https://doi.org/10.1016/j.oraloncology.2010.12.006

    Article  PubMed  Google Scholar 

  7. Calabrese L, Bizzoca ME, Grigolato R et al (2020) From bench to bedside in tongue muscle cancer invasion and back again: gross anatomy, microanatomy, surgical treatments and basic research. Life (Basel) 10(9):197. https://doi.org/10.3390/life10090197. (Published 2020 Sep 12)

    Article  PubMed  Google Scholar 

  8. Ansarin M, Bruschini R, Navach V et al (2019) Classification of GLOSSECTOMIES: proposal for tongue cancer resections. Head Neck 41(3):821–827. https://doi.org/10.1002/hed.25466

    Article  PubMed  PubMed Central  Google Scholar 

  9. Gawryszuk A, Bijl HP, Holwerda M et al (2019) Functional Swallowing Units (FSUs) as organs-at-risk for radiotherapy. PART 1: Physiology and anatomy. Radiother Oncol 130:62–67. https://doi.org/10.1016/j.radonc.2018.10.028

    Article  PubMed  Google Scholar 

  10. Gawryszuk A, Bijl HP, Holwerda M et al (2019) Functional Swallowing Units (FSUs) as organs-at-risk for radiotherapy. PART 2: Advanced delineation guidelines for FSUs. Radiother Oncol 130:68–74. https://doi.org/10.1016/j.radonc.2018.09.022

    Article  PubMed  Google Scholar 

  11. Piazza C, Grammatica A, Montalto N, Paderno A, Del Bon F, Nicolai P (2019) Compartmental surgery for oral tongue and floor of the mouth cancer: oncologic outcomes. Head Neck 41(1):110–115. https://doi.org/10.1002/hed.25480

    Article  PubMed  Google Scholar 

  12. Alterio D, Augugliaro M, Tagliabue M et al (2021) The T-N tract involvement as a new prognostic factor for PORT in locally advanced oral cavity tumors [published online ahead of print, 2021 Apr 24]. Oral Dis. https://doi.org/10.1111/odi.13885

    Article  PubMed  Google Scholar 

  13. Calabrese L, Pietrobon G, Fazio E et al (2020) Anatomically-based transoral surgical approach to early-stage oral tongue squamous cell carcinoma. Head Neck 42(5):1105–1109. https://doi.org/10.1002/hed.26095

    Article  PubMed  Google Scholar 

  14. Gazzini L, Dallari V, Fazio E (2021) How I do it: transoral surgical approach to early-stage oral tongue squamous cell carcinoma (with video). Eur Ann Otorhinolaryngol Head Neck Dis 138(Suppl 2):45–46. https://doi.org/10.1016/j.anorl.2021.02.019

    Article  PubMed  Google Scholar 

  15. Touré G, Vlavonou S, Andrianantoandro I, Ndiaye MM (2021) TNM classification: are cancers with extrinsic tongue muscle involvement systematically T4a? J Oral Maxillofac Surg 79(1):259–265. https://doi.org/10.1016/j.joms.2020.07.222

    Article  PubMed  Google Scholar 

  16. Baba A, Hashimoto K, Kayama R, Yamauchi H, Ikeda K, Ojiri H (2020) Radiological approach for the newly incorporated T staging factor, depth of invasion (DOI), of the oral tongue cancer in the 8th edition of American Joint Committee on Cancer (AJCC) staging manual: assessment of the necessity for elective neck dissection [published correction appears in Jpn J Radiol 2021 Jan;39(1):100]. Jpn J Radiol 38(9):821–832. https://doi.org/10.1007/s11604-020-00982-w

    Article  PubMed  Google Scholar 

  17. Goel V, Parihar PS, Parihar A et al (2016) Accuracy of MRI in prediction of tumour thickness and nodal stage in oral tongue and gingivobuccal cancer with clinical correlation and staging. J Clin Diagn Res 10(6):TC01-TC5. https://doi.org/10.7860/JCDR/2016/17411.7905

    Article  PubMed  PubMed Central  Google Scholar 

  18. Cai YC, Li C, Zeng DF et al (2019) Comparative analysis of radial forearm free flap and anterolateral thigh flap in tongue reconstruction after radical resection of tongue cancer. ORL J Otorhinolaryngol Relat Spec 81(5–6):252–264. https://doi.org/10.1159/000502151

    Article  PubMed  Google Scholar 

  19. Gazzini L, Dallari V, Fazio E (2021) How I do it: harvesting of radial forearm free flap (with video). Eur Ann Otorhinolaryngol Head Neck Dis 138(Suppl 2):47–48. https://doi.org/10.1016/j.anorl.2021.01.012

    Article  PubMed  Google Scholar 

  20. Choi JW, Kim YC, Park H, Oh TS, Jeong WS (2022) The impact of dynamic tongue reconstruction using functional muscle transfer: a retrospective review of 94 cases with functional outcome analysis for various glossectomy defects. J Craniomaxillofac Surg 50(9):719–731. https://doi.org/10.1016/j.jcms.2022.07.008

    Article  PubMed  Google Scholar 

  21. Molteni G, Dallari V, Caiazza N, Sacchetto A (2022) Versatility and aesthetic performance of the submental flap for reconstruction of skin defects in head and neck [published online ahead of print, 2022 Nov 24]. Am J Otolaryngol 44(2):103696. https://doi.org/10.1016/j.amjoto.2022.103696

    Article  PubMed  Google Scholar 

  22. Chen DW, Wang T, Shey-Sen Ni J et al (2019) Prognostic factors associated with achieving total oral diet after glossectomy with microvascular free tissue transfer reconstruction. Oral Oncol 92:59–66. https://doi.org/10.1016/j.oraloncology.2019.03.005

    Article  PubMed  PubMed Central  Google Scholar 

  23. Vincent A, Kohlert S, Lee TS, Inman J, Ducic Y (2019) Free-flap reconstruction of the tongue. Semin Plast Surg 33(1):38–45. https://doi.org/10.1055/s-0039-1677789

    Article  PubMed  PubMed Central  Google Scholar 

  24. Grammatica A, Piazza C, Montalto N et al (2021) Compartmental surgery for oral tongue cancer: objective and subjective functional evaluation. Laryngoscope 131(1):E176–E183. https://doi.org/10.1002/lary.28627

    Article  PubMed  Google Scholar 

  25. Suzuki K, Nishio N, Kimura H et al (2022) Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: a prospective evaluation [published online ahead of print, 2022 Dec 2]. Int J Oral Maxillofac Surg. https://doi.org/10.1016/j.ijom.2022.11.010

    Article  PubMed  Google Scholar 

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Correspondence to Virginia Dallari.

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Gazzini, L., Fazio, E., Dallari, V. et al. Beyond the boundaries of compartmental hemiglossectomy: a proposal for an anatomically based classification of surgical approaches to advanced oral tongue squamous cell carcinoma. Eur Arch Otorhinolaryngol 280, 3015–3022 (2023). https://doi.org/10.1007/s00405-023-07915-z

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  • DOI: https://doi.org/10.1007/s00405-023-07915-z

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