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Clinicopathological characteristics, treatment and prognosis of oral adenocarcinoma: a population-based study

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Abstract

Objectives

The aim of this study was to identify clinicopathologic features, treatment and prognosis of oral adenocarcinoma (OADC).

Study design

Retrospective cohort analysis.

Setting

National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) program.

Methods

Patients diagnosed with OADC between 2000 to 2018 were identified from the SEER database. Overall survival (OS) and disease-specific survival (DSS) were assessed using Kaplan–Meier analyses and Cox regression models.

Results

There were 924 OADC and 37,500 oral squamous cell carcinoma (OSCC) patients identified. Patients with OADC were more significantly associated with younger age, female gender, well differentiation and early AJCC Clinical stage. The study revealed that patients with OADC had better 10-year OS and DSS than those with OSCC (OS: 69.3% vs 40.8%, P < 0.001; DSS: 83.6% vs 53.3%, P < 0.001). The survival advantage still persisted in multivariable analyses (OS: hazard ratio [HR] = 0.427, P < 0.001; DSS: HR = 0.320, P < 0.001). For OADC, multivariable analysis showed that advanced age, stage, and histologic grade were associated with worse OS and DSS, and surgery was associated with better OS and DSS.

Conclusions

OADC has a significantly better prognosis than OSCC, with better differentiation, and more early stage. Surgery was the preferred treatment, for patients with lymph node metastasis, radiotherapy may afford a survival benefit.

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Availability of data and materials

The data that support the findings of this study were abstracted from an open database, the Surveillance, Epidemiology, and End Results (SEER) database (https://seer.cancer.gov).

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Acknowledgements

We would like to thank the National Cancer Institute’s Surveillance, Epidemiology and End Results program for providing this database.

Author information

Author notes

  1. Yiting Wang and Shijie Wang should be considered joint first author.

Authors and Affiliations

  1. Department of Stomatology, The Fifth Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou People’s Hospital, 33 Huanghe Road, Zhengzhou, 450000, China

    Yiting Wang

  2. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China

    Shijie Wang

  3. Department of Geriatrics, Henan Provincial People’s Hospital, The Affiliated People’s Hospital of Zhengzhou University, Zhengzhou, China

    Yujie Qu

  4. Medical College of Jinzhou Medical University, School of Stomatology, Jinzhou, China

    Yilin Yang

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  1. Yiting Wang
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  4. Yilin Yang
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Corresponding author

Correspondence to Yiting Wang.

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All authors have declared no conflict of interest.

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Supplementary Information

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405_2023_7912_MOESM1_ESM.tif

Supplementary Fig. 1. Subgroup analysis of the effect of radiotherapy in patients with oral adenocarcinoma. a, lip; b, tongue; c, mouth; d, palate; e, cheek mucosa; f, no lymph node metastasis; g, lymph node metastasis; h, local resection; I, radical resection (TIF 224 KB)

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Wang, Y., Wang, S., Qu, Y. et al. Clinicopathological characteristics, treatment and prognosis of oral adenocarcinoma: a population-based study. Eur Arch Otorhinolaryngol 280, 3365–3374 (2023). https://doi.org/10.1007/s00405-023-07912-2

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  • DOI: https://doi.org/10.1007/s00405-023-07912-2

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