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Subjective symptoms as predictors for eosinophilic chronic rhinosinusitis with nasal polyps in the Chinese population

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the putative association between subjective symptoms and eosinophilic inflammation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Methods

A total of 102 patients with CRSwNP who underwent endoscopic sinus surgery were prospectively enrolled. The Sinonasal Outcomes Test-22 scores (SNOT-22), EuroQol 5-dimensional Questionnaire scores (ED-5D), and Lund–Mackay scores by computed tomography (CT) were obtained. Patients were grouped as eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic CRSwNP (neCRSwNP). ECRSwNP was defined if tissue eosinophils of nasal polyps were greater than or equal to 8/HPF according to positive major basic protein (MBP) staining, and neCRSwNP otherwise.

Results

Thirty neCRSwNP and 72 eCRSwNP patients were included. ECRSwNP patients had higher incidences of asthma (p = 0.001), allergic rhinitis (p = 0.001), and ethmoid-to-maxillary opacification ratio on CT scans (p < 0.001), whereas the proportion of purulent discharge (p < 0.001) and maxillary sinus score (p = 0.002) was higher in the neCRSwNP patients. There were no significant differences between patients on the mains of the EQ-5D health utility values and total SNOT-22 score. However, eCRSwNP patients had higher SNOT-22 scores of sneezing (p = 0.006), runny nose (p < 0.001), and ear/facial domain (p = 0.012), and lower scores of thick nasal discharge (p = 0.015) and blockage (p = 0.042). Sneezing, thick nasal discharge, and blockage/congestion of nose were recognized as independent factors of CRSwNP.

Conclusion

Sneezing was an independent predictor of eCRSwNP, and thick nasal discharge and blockage/congestion of nose were independent predictors of neCRSwNP.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was funded by the Natural Science Foundation of Shanghai (No. 21ZR1411700) and the National Natural Science Foundation of China (No. 82000953).

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Author notes

  1. Chen Zhang and Huan Wang contributed equally to this work.

Authors and Affiliations

  1. ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China

    Chen Zhang, Huan Wang, Qianqian Zhang, Jiani Chen, Haoran Yu, Wangpeng Li, Haoyuan Xu, Li Hu, Dehui Wang & Xicai Sun

Authors
  1. Chen Zhang
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  2. Huan Wang
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  3. Qianqian Zhang
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  4. Jiani Chen
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  6. Wangpeng Li
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  7. Haoyuan Xu
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  8. Li Hu
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  9. Dehui Wang
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Contributions

LH, XS, and DW contributed to the conception of the study. JC, QZ, and HX contributed to performing the data analyses. CZ and HW contributed to the manuscript preparation. HY and WL helped to perform the analysis with constructive discussions. All the authors contributed to the article and approved the submitted version.

Corresponding authors

Correspondence to Li Hu, Dehui Wang or Xicai Sun.

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Zhang, C., Wang, H., Zhang, Q. et al. Subjective symptoms as predictors for eosinophilic chronic rhinosinusitis with nasal polyps in the Chinese population. Eur Arch Otorhinolaryngol 280, 3721–3729 (2023). https://doi.org/10.1007/s00405-023-07905-1

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  • DOI: https://doi.org/10.1007/s00405-023-07905-1

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