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Diagnostic value of myeloperoxidase and eosinophil cationic protein in nasal secretions for endotypes of chronic rhinosinusitis

  • Rhinology
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 14 August 2023

Abstract

Objectives

To explore associations between inflammatory endotypes and clinical presentations in CRS. To investigate the value of secretions myeloperoxidase (MPO) and eosinophilic cationic protein (ECP) detections in the diagnosis of endotypes of chronic rhinosinusitis (CRS), so as to provide guidance for the clinical application of MPO and ECP detection in secretions.

Methods

We collected clinical symptom scores from patients with CRS and examined the differences between endotypes in clinical features. Patients’ nasal secretions and polyps (or middle turbinate for control) were collected and their NEU number, EOS%, MPO and ECP levels were measured. Correlation analysis was performed for these biomarkers in secretions and tissues, respectively. Receiver operating characteristic curves were used to assess the predictive potential of the biomarkers mentioned above in nasal secretions.

Results

Patients with Eos+Neu+ and Eos+Neu−CRS scored highest in most clinical symptom scores, while Eos−Neu+ and Eos−Neu−CRS scored lowest. Correlation analysis showed that tissues NEU number was correlated with NEU number and MPO level in nasal secretions (R = 0.4088; 0.6613); tissues EOS % was correlated with EOS% and ECP level in nasal secretions (R = 0.2344; 0.5774). To diagnose Neu+CRS, the highest area under the curve (AUC) (0.8961) was determined for MPO in secretions; the highest AUC (0.7400) was determined for NEU number in secretions. To diagnose Eos+Neu−CRS from Eos−Neu−CRS in Neu−CRS, the highest AUC (0.8801) was determined for ECP in secretions.

Conclusions

Clinical presentations are directly associated with CRS endotypes. Measurement of MPO and ECP in nasal secretions is useful for the endotypes diagnosis of CRS.

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Acknowledgements

The authors thank all participants in this study for their enthusiastic cooperation.

Funding

This research was supported by the National Natural Science Foundation of China (no. 82201250), Natural Science Foundation of Hubei Province (no. 2021CFB125) and Wuhan Dabai Xiaobai Technology Co., Ltd., China (2021HX0027).

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Author notes

  1. Jing Jin and Bei Guo are co-first authors.

Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Rd., Wuhan, 430060, China

    Jing Jin, Wei Zhang, Yu-qing Deng, Rong Xiang, Lu Tan, Dan-xue Qin, Li Zheng, Ze-zhang Tao & Yu Xu

  2. Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China

    Jing Jin, Wei Zhang, Yu-qing Deng, Rong Xiang, Lu Tan, Dan-xue Qin, Li Zheng, Ze-zhang Tao & Yu Xu

  3. Department of Otolaryngology, Central Hospital of Wuhan, Wuhan, China

    Bei Guo

  4. Department of Otolaryngology-Head and Neck Surgery, Union Hospital of Tongji Medical College, Wuhan, China

    Jian-jun Chen

  5. Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430060, China

    Zhe Chen

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Correspondence to Zhe Chen, Ze-zhang Tao or Yu Xu.

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Jin, J., Guo, B., Zhang, W. et al. Diagnostic value of myeloperoxidase and eosinophil cationic protein in nasal secretions for endotypes of chronic rhinosinusitis. Eur Arch Otorhinolaryngol 280, 3707–3720 (2023). https://doi.org/10.1007/s00405-023-07903-3

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