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Association between cognition and olfaction-specific parameters in patients with chronic rhinosinusitis

  • Rhinology
  • Published:
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Abstract

Background

Patients with chronic rhinosinusitis (CRS) have reported significantly cognitive and olfactory dysfunction. This study aimed to explore the relationship between cognitive function and olfaction-specific parameters in patients with CRS.

Methods

A cross-sectional survey method was used to investigate 98 participants, including 75 patients with CRS and 23 healthy controls. Cognitive function and psychophysical olfactory tests were performed. Olfactory cleft endoscopy scale and olfactory cleft computed tomography (CT) scores were obtained. Multivariate logistic regression was used to analyze the risk factors of Mild Cognitive Impairment (MCI) in patients with CRS.

Results

There are significant differences in age, Montreal Cognitive Assessment (MoCA) scores, number of MCI, Lund-Mackay olfactory cleft (LM-OC) score, and blood eosinophil count between CRS with and without olfactory dysfunction groups (all P < 0.05). Total MoCA scores were positively correlated with thresholds-discrimination-identification (TDI) score (r = 0.541, P < 0.001), olfactory threshold (OT) (r = 0.440, P < 0.001), olfactory discrimination (OD) (r = 0.541, P < 0.001), and olfactory identification (OI) (r = 0.382, P = 0.001) scores. Furthermore, total MoCA scores were negatively correlated with LM-OC scores (r =  − 0.351, P = 0.002). After adjusting for patient demographics, only the OD score was an independent risk factor for MCI among patients with CRS (odds ratio = 0.792; P = 0.039). The OD scores less than 11.5 were the best predictor of MCI in patients with CRS.

Conclusion

Olfaction-specific clinical parameters were highly correlated with cognitive function in patients with CRS and the OD score was an independent risk factor for MCI in patients with CRS.

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Availability of data and materials

The data that support the fndings of this study are available from the corresponding author upon reasonable request.

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Funding

Natural Science Foundation of China (82000954), Beijing Science and Technology Nova Program (Z201100006820086), Beijing Hospitals Authority Youth Program (QML20190617), and Beijing Hospitals Authority Clinical Medicine Development of Special Funding (XMLX202136).

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Author notes

  1. Feifan Chang and Junsheng Hong contributed equally to this work.

Authors and Affiliations

  1. Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China

    Feifan Chang

  2. Department of Otolaryngology-Head and Neck Surgery, Xuanwu Hospital Capital Medical University, Beijing, China

    Junsheng Hong

  3. Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Fan Yuan

  4. Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Haidian District, No. 49 Huayuan North Road, Beijing, 100191, People’s Republic of China

    Dawei Wu

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  1. Feifan Chang
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All authors have made substantial contributions to the conception, analysis, and interpretation of data in this article, approved the submitted version, and agreed to be personally accountable for our contributions and to ensure that questions related to the accuracy or integrity of any part of the work, even ones in which we are not personally involved, are appropriately investigated, resolved, and the resolution documented in the literature.

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Chang, F., Hong, J., Yuan, F. et al. Association between cognition and olfaction-specific parameters in patients with chronic rhinosinusitis. Eur Arch Otorhinolaryngol 280, 3249–3258 (2023). https://doi.org/10.1007/s00405-023-07853-w

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