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The association between Helicobacter pylori and chronic otitis media with effusion

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Abstract

Purpose

Chronic otitis media with effusion (COME) is a common condition in children and a leading cause for hearing loss and ventilation tubes (VT) insertion. Among other risk factors, it is suggested that Helicobacter pylori (H. pylori) infection may have a role in the pathogenesis of COME. Previous studies have reached different results, and therefore, there is a need for further data on the relationship between H. pylori infection and COME development in children. Our objective is to investigate the presence of H. pylori in the middle-ear fluid (MEF) from children with COME.

Methods

A Comparative cross-sectional study. Children ≤ 18 years were included. The study group included children diagnosed with COME and required VT insertion. The control group included children with acute otitis media (AOM) who required myringotomy in the emergency room. Middle-ear fluid samples were sent for both culture and bacterial identification using polymerase chain reaction (PCR) testing.

Results

A total of 43 children were included. Eighteen with COME (median age 4 years, IQR 3–6), and 25 with AOM (median age 1 year, IQR 1–2). All samples were cultured for H. pylori. Twenty-two samples underwent H. pylori PCR testing of them, 12 samples from children with COME, and 10 from children with AOM. All cultures and PCR tests results were negative for H. pylori.

Conclusions

Our results suggest that H. pylori does not have a role in the pathogenesis of COME. Future larger studies are needed to investigate whether H. pylori has a role in the pathogenesis of COME.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Shamir (Assaf Harofeh) Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel

    Ahmed Taha, Jacob Pitaro, Tsilia Lazarovitch, Limor Muallem-Kalmovich, Yael Garti & Haim Gavriel

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  1. Ahmed Taha
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  2. Jacob Pitaro
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Correspondence to Ahmed Taha.

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Taha, A., Pitaro, J., Lazarovitch, T. et al. The association between Helicobacter pylori and chronic otitis media with effusion. Eur Arch Otorhinolaryngol 280, 891–896 (2023). https://doi.org/10.1007/s00405-022-07677-0

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  • DOI: https://doi.org/10.1007/s00405-022-07677-0

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