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The study of predictive factors for the evolution of vestibular schwannomas

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

The primary objective was to determine whether the analysis of textural heterogeneity of vestibular schwannomas on MRI at diagnosis was predictive of their radiological evolutivity.

The secondary objective was to determine whether some clinical or radiological factors could also be predictive of growth.

Methods

We conducted a pilot, observational and retrospective study of patients with a vestibular schwannoma, initially monitored, between April 2001 and November 2019 within the Oto-Neurosurgical Institute of Champagne Ardenne, Texture analysis was performed on gadolinium injected T1 and CISS T2 MRI sequences and six parameters were extracted: mean greyscale intensity, standard deviation of the greyscale histogram distribution, entropy, mean positive pixels, skewness and kurtosis, which were analysed by the Lasso method, using statistically penalised Cox models. Extrameatal location, tumour necrosis, perceived hearing loss < 2 years with objectified tone audiometry asymmetry, tinnitus at diagnosis, were investigated by the Log-Rank test to obtain univariate survival analyses.

Results

78 patients were included and divided into 2 groups: group A comprising 39 "stable patients", and B comprising the remaining 39 "progressive patients". Independent analysis of the texture factors did not predict the growth potential of vestibular schwannomas. Among the clinical or radiological signs of interest, hearing loss < 2 years was identified as a prognostic factor for tumour progression with a significant trend (p = 0.05).

Conclusions

This study did not identify an association between texture analysis and vestibular schwannomas growth. Decreased hearing in the 2 years prior to diagnosis appears to predict potential radiological progression.

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Abbreviations

VS:

Vestibular schwannoma

CPA:

Cerebellopontine angle

MRI:

Magnetic resonance imaging

ROI:

Region of interest

ICC:

Interclass correlation coefficient

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Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Department of Oto-Rhino-Laryngology and Head and neck surgery of the CHU of Reims, Hôpital Robert Debré, Rue du Général Koenig, 51100, Reims, France

    Le-Uyen France Truong, Esteban Brenet, Marc Labrousse & Xavier Dubernard

  2. Department of Radiology of the CHU of Reims, Hôpital Robert Debré, Rue du Général Koenig, 51100, Reims, France

    Carole Durot & Christine Hoeffel

  3. Research and Public Health Unit of the CHU of Reims, Hôpital Robert Debré, Rue du Général Koenig, 51100, Reims, France

    Coralie Barbe

  4. Department of Neurosurgery of the CHU of Reims, Hôpital Maison Blanche, 45 rue Cognacq-Jay, 51100, Reims, France

    Jean Charles Kleiber & Arnaud Bazin

  5. Faculty of Medicine, Reims Champagne Ardenne University, 51100, Reims, France

    Jean Charles Kleiber, Carole Durot, Esteban Brenet, Coralie Barbe, Christine Hoeffel, Arnaud Bazin, Marc Labrousse & Xavier Dubernard

  6. Service d’ORL et Chirurgie cervico-faciale, CHU of Reims, Hôpital Robert Debré, Rue du Général Koenig, 51100, Reims, France

    Xavier Dubernard

Authors
  1. Le-Uyen France Truong
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  2. Jean Charles Kleiber
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  9. Xavier Dubernard
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Contributions

LUFT: is the first author, designed the study, collected and interpreted the data, drafted the initial manuscript, reviewed and revised the manuscript. JCK: critically reviewed the manuscript for important intellectual content. CD: contributed to designing the study, reviewed and revised the manuscript. EB: critically reviewed the manuscript for important intellectual content. CB: contributed to designing the study, reviewed and revised the manuscript. CH: critically reviewed the manuscript for important intellectual content. AB: critically reviewed the manuscript for important intellectual content. ML: critically reviewed the manuscript for important intellectual content. XD: conceptualized, coordinated and supervised the study, interpreted the data, drafted the initial manuscript, reviewed, and revised the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Xavier Dubernard.

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Conflict of interest

The authors have no competing interests to declare that are relevant to the content of this article.

Ethics approval

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The clinical research directorate of our institution (Reims University Hospital) does not require institutional review board or ethics committee review for this type of study.

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All participants were informed of the possibility of using their information for biomedical research purposes and had the right to refuse or withdraw their consent at any time.

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Truong, LU.F., Kleiber, J.C., Durot, C. et al. The study of predictive factors for the evolution of vestibular schwannomas. Eur Arch Otorhinolaryngol 280, 1661–1670 (2023). https://doi.org/10.1007/s00405-022-07651-w

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  • DOI: https://doi.org/10.1007/s00405-022-07651-w

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