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Oncological outcomes of cervical esophageal cancer treated primarily with surgery: a systematic review and meta-analysis

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Abstract

Purpose

To determine the oncological outcomes of cervical esophageal cancer (CEC) treated primarily with surgery.

Methods

A systematic review and meta-analysis was performed according to the PRISMA guidelines.

Results

A total of 868 patients were included from 18 studies. Estimated pooled Overall Survival (OS) rates (95% Confidence Interval, CI) at 1 and 5 years were 74.4% (66.5–83.3), and 26.6% (20.3–34.7), respectively. Larynx non-preserving surgery (n = 229) showed an estimated pooled OS rates (95% CI) at 1 and 5 years of 59.3% (51.5–68.2) and 14.6% (8.8–24.3), respectively. On the other hand, larynx preserving surgery (n = 213) showed an estimated pooled OS rates (95% CI) at 1 and 5 years of 83.6% (78.2–89.4) and 35.1% (24.9–49.6), respectively.

Conclusions

Primary larynx-preserving surgery remains a valuable option for the management of CEC, with similar survival outcomes compared to primary chemoradiotherapy (CRT). On the other hand, larynx non-preserving surgery showed a significantly reduced survival, that may reflect the more advanced T classification of these tumors. Further studies are mandatory to directly compare primary surgery and primary CRT, distinguishing larynx preserving and non-preserving surgery.

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Funding

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Author information

Author notes

  1. Armando De Virgilio and Andrea Costantino contributed equally.

  2. Carlo Castoro and Giuseppe Spriano contributed equally.

Authors and Affiliations

  1. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090, Milan, Italy

    Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Ciro Franzese, Marta Scorsetti, Carlo Castoro & Giuseppe Spriano

  2. Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy

    Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante & Giuseppe Spriano

  3. Radiotherapy Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy

    Davide Franceschini, Ciro Franzese & Marta Scorsetti

  4. Oncology Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy

    Andrea Marrari & Raffaele Cavina

  5. Division of Upper Gastrointestinal Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy

    Salvatore Marano & Carlo Castoro

Authors
  1. Armando De Virgilio
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  2. Andrea Costantino
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  3. Bianca Maria Festa
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Correspondence to Bianca Maria Festa.

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De Virgilio, A., Costantino, A., Festa, B. et al. Oncological outcomes of cervical esophageal cancer treated primarily with surgery: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 280, 373–390 (2023). https://doi.org/10.1007/s00405-022-07589-z

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  • DOI: https://doi.org/10.1007/s00405-022-07589-z

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