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The effect of type 1 diabetes mellitus on voice in pediatric patients

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this prospective case–control study was to determine the effect on the voice of type 1 diabetes mellitus (T1DM) in paediatric patients.

Materials and methods

The study included patients aged 6–18 years followed up for at least 1 year because of T1DM, and a control group of age and gender-matched healthy volunteers. Following an Ear, Nose, and Throat (ENT) examination, all subjects underwent flexible endoscopic laryngeal examination. Fasting venous blood samples were taken in the morning for the examination of fasting blood glucose (FBG), HgbA1C, and kidney, liver, and thyroid function tests. Data were recorded from the patient files of age, gender, comorbidities, and the development of diabetes-related complications. Voice recordings were taken and the Voice Handicap Index (VHI)-10 form was completed. The patients and control group were compared in respect of the parameters of fundamental frequency, jitter, shimmer, and acoustic voice quality index (AVQI).

Results

Evaluation was made of 64 children and adolescents as 32 in the patient group (Group 1) and 32 healthy control subjects (Group 2). Group 1 comprised 17 females and 15 males with a mean age of 12.75 ± 3.23 years. Group 2 comprised 17 females and 15 males with a mean age of 12.75 ± 3.33 years. In Group 1, mean disease duration was 5.21 ± 3.17 years (range, 1–13 years), the FBG value was mean 216.6 ± 122.3 mg/dl, mean HgbA1c was 10.7 ± 2.8, as ≤ 7 in 4 patients, 7–9 in 4, and > 9 in 24. Maximum phonation time (MPT) was determined as 10.66 ± 3.6 secs in Group 1 and 12.11 ± 4.43 in Group 2. VHI was determined as 2.33 ± 3 in Group 1 and 2.31 ± 2.77 in Group 2. No statistically significant difference was determined between the groups was determined in respect of acoustic analysis, perturbation parameters, AVQI and body mass index.

Conclusions

This study is the first to have investigated the effects of T1DM on the voice in paediatric patients. The study results showed that the AVQI value was higher in the patient group but not to a statistically significant level. Therefore, there is a need for further studies with larger samples. The current study can be of guidance for further studies in this field.

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Data availability

The data that support the findings of this study are available on request from the corresponding author.

Availability of data and materials

The data sets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors did not receive support from any organization for the submitted work.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Otolaryngology, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey

    Irfan Kara, Saime Sagıroglu, Muhammed Gazi Yıldız, Nagihan Bilal & Israfil Orhan

  2. Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

    Fatih Temiz

  3. Faculty of Medicine, Department of Bioistatistics, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

    Adem Doganer

Authors
  1. Irfan Kara
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  2. Fatih Temiz
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  3. Adem Doganer
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  4. Saime Sagıroglu
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  5. Muhammed Gazi Yıldız
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  6. Nagihan Bilal
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Correspondence to Irfan Kara.

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Kara, I., Temiz, F., Doganer, A. et al. The effect of type 1 diabetes mellitus on voice in pediatric patients. Eur Arch Otorhinolaryngol 280, 269–275 (2023). https://doi.org/10.1007/s00405-022-07543-z

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  • DOI: https://doi.org/10.1007/s00405-022-07543-z

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