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Increased risk of olfactory and taste dysfunction in the United States psoriasis population

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Background

It is plausible that immunopathological processes associated with psoriasis might contribute to the occurrence of olfactory or taste dysfunction. However, the actual association was still unknown.

Purpose

To determine the relationship between olfactory or taste dysfunction and psoriasis.

Methods

Two cross-sectional studies were performed by using National Health and Nutrition Examination Survey (NHANES) data. Participants with psoriasis were defined as cases and those without psoriasis were identified as controls. Taste and smell self-reported questionnaires were used to define smell/taste alterations and identification tests were used to assure the smell/taste dysfunctions. Logistic regression models with inverse probability treatment weighting (IPTW) strategies were conducted to investigated the relationship between psoriasis and olfactory or taste dysfunction.

Results

Self-reported questionnaires indicated that psoriasis patients were more likely to have perceived taste alteration (IPTW-aOR = 1.43) and smell alteration (IPTW-aOR = 1.22). Identification tests revealed that psoriasis was associated with taste dysfunction (IPTW-aOR = 1.28) and olfactory dysfunction (IPTW-aOR = 1.22). Relevant findings showed that psoriasis may be significantly associated with taste or olfactory dysfunction regardless of the questionnaire data or identification examination data used.

Conclusion

Olfactory and taste dysfunction could be considered comorbidities in patients with psoriasis based on our observational study. Therefore, physicians should be cautious of olfaction and taste alterations among patients with psoriasis.

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Author information

Authors and Affiliations

  1. Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan

    Pei-Xun Zhong, I.-Hsun Li & Li-Ting Kao

  2. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan

    Pei-Xun Zhong, I.-Hsun Li & Li-Ting Kao

  3. Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

    Yi-Hsien Chen

  4. Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan

    I.-Hsun Li

  5. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

    Yuan-Liang Wen, Hui-Han Kao & Li-Ting Kao

  6. Science and Technology Policy Research and Information Center, National Applied Research Laboratories, Taipei, Taiwan

    Hui-Han Kao

  7. School of Public Health, National Defense Medical Center, Taipei, Taiwan

    Hui-Han Kao & Li-Ting Kao

  8. Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan

    Kuan-Wei Chiang

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  1. Pei-Xun Zhong
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Zhong, PX., Chen, YH., Li, IH. et al. Increased risk of olfactory and taste dysfunction in the United States psoriasis population. Eur Arch Otorhinolaryngol 280, 695–702 (2023). https://doi.org/10.1007/s00405-022-07530-4

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  • DOI: https://doi.org/10.1007/s00405-022-07530-4

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