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High recurrence rate in patients with juvenile-onset respiratory papillomatosis and its risk factors

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To identify the recurrence rate and risk factors for recurrence in patients with juvenile-onset recurrent respiratory papillomatosis (JORRP).

Methods

A retrospective review was performed for all JORRP patients who underwent surgery between 2002 and 2019 at our institution. The demographic characteristics and clinical parameters were recorded. Kaplan–Meier estimates and Cox proportional hazards models were used to analyze the rate of recurrence and its risk factors.

Results

Our study included 721 patients. The cumulative recurrence rates at 1, 5, and 10 postoperative years following initial surgery were 74.2%, 90.0%, and 94.3%, respectively. Age at diagnosis younger than 4.5 years (HR = 2.380, 95% CI [1.169–4.846], P = 0.017), high Derkay anatomical score (HR = 1.136, 95% CI [1.043–1.236], P = 0.003) and HPV type 11 infection (HR = 2.947, 95% CI [1.326–6.551], P = 0.008) were independent risk factors for recurrence. Adjuvant therapy with interferon was less likely to recur (HR = 0.237, 95% CI [0.091–0.616], P = 0.003). Additionally, gender, tracheotomy, mode of delivery, parity, expression of Ki-67, HPV vaccination, and surgical treatment method were not independently associated with recurrence (P > 0.05).

Conclusion

Age at diagnosis younger than 4.5 years, high Derkay anatomical score and HPV type 11 infection were associated with an increased risk for recurrence in patients with JORRP. Adjuvant therapy with interferon may reduce the risk of recurrence.

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Availability of data and material

The datasets analyzed during the current study are available from the corresponding authors on reasonable request.

Code availability

Not applicable.

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Funding

This work was supported by the Pediatric special project of pediatric subject collaborative development center of Beijing Municipal Hospital Administration under Grant Number XTCX201823; and Beijing Administration of Traditional Chinese Medicine under Grant Number JJ-2020–17.

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Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Xiaoli Qu, Yang Xiao, Lijing Ma, Zijie Niu & Jun Wang

  2. Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China

    Xiaoli Qu, Yang Xiao, Lijing Ma, Zijie Niu & Jun Wang

Authors
  1. Xiaoli Qu
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  2. Yang Xiao
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  3. Lijing Ma
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  4. Zijie Niu
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  5. Jun Wang
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Contributions

XQ performed the data collection, analyzed the data and wrote the manuscript. YX and ZN were responsible for follow-up. LM helped perform the analysis with constructive discussions. JW designed the study and provided financial support for this work, and is to be considered as the corresponding authors. All authors reviewed the manuscript.

Corresponding author

Correspondence to Jun Wang.

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The authors declare no conflict of interests.

Ethics approval

The study protocol was approved by the ethics committee of Beijing Tongren Hospital, Capital Medical University in China (TRECKY2021-015).

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This was a retrospective study, thus no informed consent was needed.

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Qu, X., Xiao, Y., Ma, L. et al. High recurrence rate in patients with juvenile-onset respiratory papillomatosis and its risk factors. Eur Arch Otorhinolaryngol 279, 4061–4068 (2022). https://doi.org/10.1007/s00405-022-07390-y

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  • DOI: https://doi.org/10.1007/s00405-022-07390-y

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