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Table 4 Differences in EOTC-C30 and EORTC H&N35 dimensions between assessments at baseline and at 5 years after free flap surgery for cancer of the head and neck

From: Quality of life in head and neck cancer patients at 5 years after free flap reconstruction: a significant decline during the follow-up

Dimension 5-year value Baseline Difference P value
EORTC-C30
 Global health status 64.6 (24.0) 83.9 (16.4) − 19.3 (− 27.6 to 11.07)  < 0.001
Functional scales
 Physical functioning 71.4 (22.6) 86.0 (18.2) − 14.6 (− 11.0 to − 8.6)  < 0.001
 Role functioning 82.1 (22.2) 91.1 (18.4) − 8.9 (17.8 to − 0.05) 0.049
 Emotional functioning 84.2 (16.3) 90.5 (11.5) − 6.3 (-12.0 to − 0.5) 0.034
 Cognitive functioning 81.5 (21.9) 90.5 (11.5) − 8.9 (− 15.1 to − 2.7) 0.007
 Social functioning 81.0 (18.6) 89.9 (12.3) − 8.9 (19.3 to − 1.4) 0.087
Symptom scales
 Fatigue 30.2 (20.5) 13.1 (15.7) 17.1 (11.0 to 23.1)  < 0.001
 Nausea and vomiting 4.5 (11.9) 1.8 (5.2) 2.7 (− 1.6 to 7.0) 0.213
 Pain 29.8 (23.3) 14.9 (16.6) 14.9 (7.3 to 22.4)  < 0.001
 Dyspnea 15.5 (24.8) 10.7 (24.1) 4.8 (− 2.0 to 14.6) 0.161
 Insomnia 28.6 (25.2) 19.0 (24.7) 9.5 (1.0 to 18.0) 0.030
 Appetite loss 9.5 (20.0) 3.6 (10.5) 6.0 (− 2.7 to 14.6) 0.170
 Constipation 13.1 (22.8) 8.3 (14.7) 4.8 (− 5.6 to 15.1) 0.355
 Diarrhea 9.5 (17.8) 2.4 (8.7) 7.1 (0.7 to 13.6) 0.031
 Financial difficulties 15.5 (24.8) 13.1 (22.8) 2.4 (− 6.9 to 11.6) 0.602
EORTC H&N35 symptom scales
 Pain 22.0 (20.2) 17.6 (17.9) 4.5 (1.0 to 9.9) 0.105
 Swallowing 23.1 (23.4) 16.7 (21.8) 3.5 (− 4.1 to 11.2) 0.354
 Senses problems 11.3 (20.8) 16.7 (21.8) − 5.4 (− 10.0 to − 0.7) 0.026
 Speech problems 27.2 (20.3) 20.2 (21.8) 7.0 (− 0.5 to 14.5) 0.067
 Trouble with social eating 11.1 (21.2) 27.5 (27.5) − 16.4 (–29.4 to -3 3) 0.016
 Trouble with social contact 18.8 (16.9) 11.0 (13.2) 7.8 (3.3 to 12.4) 0.001
 Less sexuality 51.3 (41.1) 26.7 (32.6) 24.7 (7.7 to 41.6) 0.006
 Teeth 29.8 (35.5) 29.8 (37.7) 0 (− 18.6 to 18.6)  > 0.9
 Opening mouth 39.3 (37.7) 32.1 (34.5) 7.1 (− 5.7 to 20.0) 0.264
 Dry mouth 39.3 (32.8) 44.0 (34.0) − 4.7 (− 18.3 to 8.7) 0.475
 Sticky saliva 32.1 (34.5) 23.8 (31.2) 8.3 (− 4.2 to 20.8) 0.183
 Coughing 21.4 (25.4) 9.5 (17.8) 11.9 (2.5 to 21.4) 0.015
 Felt ill 23.8 (25.4) 6.0 (17.8) 17.9 (8.9 to 26.8)  < 0.001
 Pain killers 16.7 (17.0) 35.7 (48.9) − 19.0 (− 36.1 to − 2.0) 0.030
 Nutritional supplements 13.1 (16.6) 25.0 (21.0) − 11.9 (− 28.9 to 5.0) 0.161
 Feeding tube 10.7 (31.5) 3.6 (10.5) 7.1 (1.0 to 15.3) 0.083
 Weight loss 3.6 (10.5) 3.6 (18.9) 0.0 (− 8.6 to 8.6) 1.0
 Weight gain 4.8 (11.9) 17.9 (39.0) − 13.1 (− 28.6 to 2.4) 0.094