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Open partial horizontal laryngectomy for T2–T3–T4a laryngeal cancer: oncological outcomes and prognostic factors of two Italian hospitals

  • Laryngology
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Abstract

Purpose

The purpose of this study was to analyse the oncologic results of open partial horizontal laryngectomy (OPHL) and to assess the prognostic factors that could affect the survival of patients affected by T2, T3 and T4a laryngeal cancer. Using this data, we aim to identify clinical criteria to select patients amenable to conservative surgery, and to facilitate a more targeted approach in the management of advanced laryngeal cancer.

Methods

A retrospective study was performed in patients who underwent OPHL type II for laryngeal squamous cell carcinoma from January 2005 to December 2018. We analysed a total of 170 patients; 21(12.36%) cases were staged as pT2, 116 (68.23%) as pT3 and 33 (19.41%) as pT4a.

Results

Five-year overall survival (OS) was 80.9%, 79.3%, 70.4% for T2, T3 and T4 respectively. Disease-specific survival (DSS) was 90.4%, 85.3% and 77.4%. Posterior tumour extension, perineural invasion and N status showed to considerably influence survival in both uni- and multivariate analyses.

Conclusion

The oncological outcomes from our study show that OPHL for advanced laryngeal cancer can guarantee a high percentage of success. Accurate patient selection is of utmost importance to differentiate advanced disease amenable to conservative surgery, and treatment options should consider selected criteria based on tumour and patient features.

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Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

    Marco de Vincentiis

  2. Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy

    Antonio Greco, Flaminia Campo, Francesca Candelori, Massimo Ralli, Andrea Colizza & Francesca Cambria

  3. Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy

    Mario Di Traglia

  4. Department of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy

    Flaminia Campo, Jacopo Zocchi, Valentina Manciocco & Raul Pellini

  5. Otorhinolaryngology Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy

    Giuseppe Spriano

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  1. Marco de Vincentiis
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Contributions

MdV: substantial contributions to the conception and design of the work; examined title and abstract; analysis, and interpretation of data; revising the work; final approval of the version to be published; agreement to be accountable for all aspects of the work. AG: substantial contributions to the conception and design of the work; examined title and abstract; analysis, and interpretation of data; revising the work; final approval of the version to be published; agreement to be accountable for all aspects of the work. FC: substantial contributions to the conception and design of the work; examined title and abstract; analysis, and interpretation of data; revising the work; final approval of the version to be published; agreement to be accountable for all aspects of the work. FC: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. MR: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. MDT: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. AC: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. FC: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. JZ: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. VM: drafting of the manuscript and revising it for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work. GS: substantial contributions to the conception and design of the work; examined title and abstract; analysis, and interpretation of data; revising the work; final approval of the version to be published; agreement to be accountable for all aspects of the work. RP: substantial contributions to the conception and design of the work; examined title and abstract; analysis, and interpretation of data; revising the work; final approval of the version to be published; agreement to be accountable for all aspects of the work.

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Correspondence to Andrea Colizza.

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de Vincentiis, M., Greco, A., Campo, F. et al. Open partial horizontal laryngectomy for T2–T3–T4a laryngeal cancer: oncological outcomes and prognostic factors of two Italian hospitals. Eur Arch Otorhinolaryngol 279, 2997–3004 (2022). https://doi.org/10.1007/s00405-021-07238-x

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