Abstract
Background
Difficult-to-treat rhinosinusitis (DTRS) seriously affects the quality of work and life of patients, and the cause is still unclear. We aimed to explore the association between the glucocorticoid receptor (NR3C1) gene polymorphisms and DTRS.
Methods
A nested case–control study was conducted. The exons of NR3C1 gene were sequenced by an ABI 9700 DNA analyzer in 30 DTRS patients and 70 matched chronic rhinosinusitis (CRS) patient with good outcome (non-DTRS). The genotypic and allele frequencies were calculated and linkage disequilibrium was analyzed.
Results
The three SNPs showed a significant difference between the DTRS and non-DTRS groups. In allelic model analysis, we found that the allele “C” of rs6196, the allele “A” of rs258751, and the allele “T” of rs6194 were associated with increased the risk of DTRS (all p < 0.05). In addition, the haplotype CAT of the 3 SNPs was detected to be significantly associated with DTRS risk (p = 0.001), while the haplotype TGC was associated with the decreased risk of DTRS (p = 0.008).
Conclusion
NR3C1 gene polymorphisms are significantly associated with the DTRS.
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Acknowledgements
The authors thank all medical staff and graduate students of the Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Anzhen Hospital.
Funding
This study was supported by Capital Health Research and Development of Special Fund (2018-2-2065).
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The project has been registered in the Chinese Clinical Trial Registry (ChiCTR1900022007), and approved by the Medical Ethics Committee of Beijing Anzhen Hospital (ethical approval number: 2018059X).
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Wu, C., Fang, F., Zhan, X. et al. The association between glucocorticoid receptor (NR3C1) gene polymorphism and difficult-to-treat rhinosinusitis. Eur Arch Otorhinolaryngol 279, 3981–3987 (2022). https://doi.org/10.1007/s00405-021-07228-z
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DOI: https://doi.org/10.1007/s00405-021-07228-z