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Evaluation of retrootolithic function using galvanic vestibular-evoked myogenic potentials in patients with benign paroxysmal positional vertigo

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

The purpose is to investigate possible vestibulopathy in patients with benign paroxysmal positional vertigo (BPPV), inner ear tests, including cervical and ocular vestibular-evoked myogenic potentials (cVEMPs and oVEMPs) via various stimulation modes, were adopted.

Methods

Fifty BPPV patients were enrolled in this study. All patients underwent pure tone audiometry, cVEMPs, oVEMPs, and caloric tests. The recurrence status, abnormal rates of inner ear tests, and the characteristic parameters of VEMPs, such as wave latencies and amplitudes, were analyzed.

Results

In affected ears, the abnormal rates of acoustic cVEMPs, vibratory oVEMPs, galvanic cVEMPs, and galvanic oVEMPs were 62%, 28%, 36%, and 14%, respectively. The abnormalities of acoustic cVEMPs were significantly larger than those of vibratory oVEMPs, and acoustic/vibratory VEMPs had significantly higher abnormal rates than the corresponding galvanic VEMPs.

Conclusion

BPPV patients may have both otolithic and neural dysfunctions. Otolithic organ damage occurs more frequently than retrootolithic neural degeneration, and the saccular macula might have a greater extent of damage than the utricular macula.

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Funding

This work was supported by Far Eastern Memorial Hospital (Grant number FEMH-2016-C-029).

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Chih-Ming Chang

  2. Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan

    Chih-Ming Chang, Wu-Chia Lo, Li-Jen Liao, Po-Hsuan Wu, Ping-Chia Cheng & Po-Wen Cheng

  3. Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan

    Chih-Ming Chang, Wu-Chia Lo, Yi-Ho Young, Li-Jen Liao & Po-Wen Cheng

  4. Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan

    Wu-Chia Lo

  5. Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan

    Li-Jen Liao

  6. Medical Engineering Office, Far Eastern Memorial Hospital, Taipei, Taiwan

    Li-Jen Liao

  7. Department of Communication Engineering, Oriental Institute of Technology, Taipei, Taiwan

    Po-Hsuan Wu

Authors
  1. Chih-Ming Chang
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  2. Wu-Chia Lo
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Contributions

Conception and the design of the work: CM Chang and PW Cheng. The acquisition of data and drafting of the manuscript: CM Chang, WC Lo, YH Young, LJ Liao, PH Wu, PC Cheng, and PW Cheng. The analysis and interpretation of data: CM Chang and PW Cheng. Supervisor: PW Cheng. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Po-Wen Cheng.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethics approval

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Research Ethics Review Committee of Far Eastern Memorial Hospital approved this study (No. 104136-E).

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Chang, CM., Lo, WC., Young, YH. et al. Evaluation of retrootolithic function using galvanic vestibular-evoked myogenic potentials in patients with benign paroxysmal positional vertigo. Eur Arch Otorhinolaryngol 279, 3415–3423 (2022). https://doi.org/10.1007/s00405-021-07094-9

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