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A retrospective study of 44 patients with head and neck Castleman’s disease

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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To explore the clinical and pathological features, therapy and prognosis of Castleman’s disease (CD) in the head and neck.

Methods

We retrospectively analyzed the clinical and pathological data of 44 patients with head and neck CD who were diagnosed in the Fujian Medical University Union hospital (Fujian, China) between May 2008 and June 2021. According to the clinical classification, they were divided into two groups, the unicentric CD (UCD, n = 20) and the multicentric CD (MCD, n = 24). Their clinical features, imaging findings, laboratory examination, and treatment results were, respectively, analyzed.

Results

The age of UCD patients was younger than that of MCD patients. Most of the UCD patients (80%) were female, with asymptomatic single lymphadenectasis, and the prognosis was favorable; while 70.8% of the MCD patients were male, with multiple lymph nodes throughout the body, and more prone to hepatosplenomegaly, pneumonia, serous effusion, anemia, hypoalbuminemia, elevated globulin, coagulation disorders, etc., the prognosis was bleak. Two cases of MCD patients were with systemic lupus erythematosus (SLE).

Conclusions

UCD usually manifests as asymptomatic single lymph node enlargement, complete surgical resection was the mainstay of treatment modality. MCD has relatively complicated clinical symptoms and poor prognosis, and anti-IL-6 therapy may be effective.

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Author notes

  1. Taiqin Wang and Xiaoqiang Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology, Fujian Medical University Union Hospital, 29# Xinquan Road, Fuzhou, 350001, Fujian, China

    Taiqin Wang, Xiaoqiang Chen, Wei Chen, Liangwen Shi & Jianzhi Liu

Authors
  1. Taiqin Wang
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  2. Xiaoqiang Chen
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  3. Wei Chen
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  4. Liangwen Shi
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  5. Jianzhi Liu
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Corresponding author

Correspondence to Jianzhi Liu.

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The authors declare that they have no conflict of interest.

Ethical approval

All the procedures performed in this study involving human participants were following the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments.

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This was retrospective study, thus no informed consent was needed.

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Wang, T., Chen, X., Chen, W. et al. A retrospective study of 44 patients with head and neck Castleman’s disease. Eur Arch Otorhinolaryngol 279, 2625–2630 (2022). https://doi.org/10.1007/s00405-021-07065-0

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  • DOI: https://doi.org/10.1007/s00405-021-07065-0

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