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Association between the circulating superoxide dismutase and obstructive sleep apnea: a meta-analysis

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Abstract

Purpose

Although it has been reported that superoxide dismutase (SOD) is related to obstructive sleep apnea (OSA), the results are controversial. In addition, the effects of the continuous positive airway pressure (CPAP) treatment on SOD levels are also inconsistent. The primary purpose of the present meta-analysis is to determine the relationship between the circulating SOD levels and OSA.

Methods

The studies included in this meta-analysis were selected from the PubMed, Embase, Cochrane Library, and Scopus databases. Two researchers independently reviewed the studies. Data analysis was performed using Stata 15.1. The overall effects were measured using the standardized mean difference (SMD) with a 95% confidence interval (CI). A random-effects model or a fixed-effects model was used, depending on the heterogeneity of the studies.

Results

A total of 14 studies were included, comprising 1240 patients and 457 controls. The results showed that the circulating SOD levels of the patients with OSA were significantly lower than that of the control group (SMD = − 1.645, 95% CI = − 2.279 to − 1.011, P < 0.001). We also studied changes in the circulating SOD levels in patients with OSA after the CPAP treatment. No significant difference was observed in the circulating SOD levels after the CPAP treatment (SMD = − 0.028, 95% CI = − 0.218 to 0.162, P = 0.772).

Conclusion

The results suggested that patients with OSA have reduced levels of SOD and were related to disease severity. The results also indicated that circulating SOD levels may be a reliable marker for detecting systemic oxidative stress in patients with OSA. However, the circulating SOD levels were not affected by the short-term (4–12 weeks) CPAP treatment. Therefore, further large-scale, well-designed randomized controlled trials with a longer CPAP therapy (more than 6 months preferably) and good adherence to the treatment are needed to investigate this issue.

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Acknowledgements

This work was supported by the Chinese National Natural Science Foundation (grant number: 81670080).

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Authors and Affiliations

  1. Department of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China

    Zongsheng Tian, Hongying Sun, Jing Kang, Zhuangzhuang Mu & Mingxian Li

  2. Department of Pediatric Neurology, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China

    Jianmin Liang

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  1. Zongsheng Tian
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Correspondence to Jianmin Liang or Mingxian Li.

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Tian, Z., Sun, H., Kang, J. et al. Association between the circulating superoxide dismutase and obstructive sleep apnea: a meta-analysis. Eur Arch Otorhinolaryngol 279, 1663–1673 (2022). https://doi.org/10.1007/s00405-021-07064-1

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