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An epidemiological survey of gastroesophageal reflux disease at the digestive endoscopy center in Guangzhou

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 11 August 2021

Abstract

Objective

This study aims to investigate the detection rates, common symptoms and risk factors of gastroesophageal reflux disease (GERD), and laryngopharyngeal reflux disease (LPRD) at the digestive endoscopy center.

Methods

A multicenter cross-sectional survey conducted at three hospitals and a total of 565 eligible participants were enrolled. All the patients completed routine ENT examination, gastroscopy, gastroesophageal reflux questionnaire (GerdQ), reflux symptom index (RSI) and a self-designed 25-item symptoms table survey.

Results

Among the 565 eligible participants, the detection rates of GERD and LPRD were 18.41% (104/565) and 9.91% (56/565), respectively. The detection rate of GERD combined with LPRD was 3.19% (18/565). Among GERD and LPRD patients, males (vs. females), middle-aged and elderly patients (vs. young people), BMI ≥ 24.0 kg/m2 (vs. BMI < 24.0 kg/m2), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking), lying down immediately after meal (vs. no lying down immediately after meal) were significantly higher (all p < 0.05). The most common extraesophageal symptoms in patients with GERD were dry mouth (66.35%), globus sensation (56.73%), dry throat and pharyngeal itching (55.77%). The most common extraesophageal symptoms in patients with LPRD were globus sensation (91.07%), dry throat and pharyngeal itching (83.93%), and dry mouth (82.14%).

Conclusion

GERD and LPRD had a high detection rate at the digestive endoscopy center in Guangzhou, China. Older age, BMI ≥ 24.0 kg/m2, smoking and drinking history were risk factors for both GERD and LPRD. Neither GerdQ nor RSI scores included common extraesophageal symptoms.

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References

  1. Mathus-Vliegen L, Toouli J, Fried M, Khan AG, Garisch J, Hunt R et al (2012) World gastroenterology organisation global guidelines on obesity. J Clin Gastroenterol 46(7):555–561. https://doi.org/10.1097/MCG.0b013e318259bd04

    Article  PubMed  Google Scholar 

  2. Hom C, Vaezi MF (2013) Extra-esophageal manifestations of gastroesophageal reflux disease: diagnosis and treatment. Drugs 73(12):1281–1295. https://doi.org/10.1007/s40265-013-0101-8

    Article  CAS  PubMed  Google Scholar 

  3. Barry DW, Vaezi MF (2010) Laryngopharyngeal reflux: more questions than answers. Clevel Clin J Med 77(5):327–334. https://doi.org/10.3949/ccjm.77a.09121

    Article  Google Scholar 

  4. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group (2007) The Montreal definition and classification of gastroesophageal reflux disease: a global, evidence-based consensus paper. Z Gastroenterol 45(11):1125–1140. https://doi.org/10.1055/s-2007-963633

    Article  Google Scholar 

  5. Capagnolo AM, Priston J, Heidrichthoen R, Medeiros T, Assuncao RA (2014) Laryngopharyngeal reflux: diagnosis, treatment, and latest research. Int Arch Otorhinolaryngol 18(2):184–191. https://doi.org/10.1055/s-0033-1352504

    Article  Google Scholar 

  6. Sidhwa F, Moore A, Alligood E, Fisichella PM (2013) Extra-esophageal manifestations of gastroesophageal reflux disease: diagnosis and treatment. Drugs 73(12):1281–1295. https://doi.org/10.1007/s40265-013-0101-8

    Article  CAS  Google Scholar 

  7. Dent J, El-Serag HB, Wallander MA, Johansson S (2005) Epidemiology of gastroesophageal reflux disease: a systematic review. Gut 54:710–717. https://doi.org/10.1136/gut.2004.051821

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Vaezi Michael F, Daniel S (2018) Assessing old and new diagnostic tests for gastroesophageal reflux disease. Gastroenterol 154(2):289–301. https://doi.org/10.1053/j.gastro.2017.07.040

    Article  CAS  Google Scholar 

  9. Lechien Jerome R, Sven S, Karkos Petros D (2018) Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018. [J]. Curr Opin Otolaryngol Head Neck Surg 26:392–402. https://doi.org/10.1097/MOO.0000000000000486

    Article  CAS  PubMed  Google Scholar 

  10. Wong WM, Lam SK, Lam KF et al (2003) A validated symptom questionnaire (Chinese-GERDQ) for the diagnosis of gastroesophageal reflux disease in Chinese population [J]. Gastroenterology 124(4):A540–A541. https://doi.org/10.1016/S0016-5085(03)82733-6

    Article  Google Scholar 

  11. Li J, Zhang L, Zhang C (2016) Linguistic adaptation, reliability, validation, and responsivity of the Chinese version of reflux symptom index. J Voice Off J Voice Found 30(1):104–108. https://doi.org/10.1016/j.jvoice.2013.12.006

    Article  Google Scholar 

  12. Lundell LR, Dent J, Bennett JR et al (1999) Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 45(2):172–180. https://doi.org/10.1136/gut.45.2.172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Jones R, Junghard O, Dent J et al (2009) Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther 30(10):1030–1038. https://doi.org/10.1111/j.1365-2036.2009.04142.x

    Article  CAS  PubMed  Google Scholar 

  14. Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the reflux symptom index (RSI). J Voice Off J Voice Found 16(2):274–277. https://doi.org/10.1016/s0892-1997(02)00097-8

    Article  Google Scholar 

  15. Groome M, Cotton JP, Borland M et al (2007) Prevalence of laryngopharyngeal reflux in a population with gastroesophageal reflux. Laryngoscope 117(8):1424–1428. https://doi.org/10.1097/MLG.0b013e31806865cf

    Article  PubMed  Google Scholar 

  16. Sataloff RT, Hawkshaw MJ, Gupta R (2010) Laryngopharyngeal reflux and voice disorders: an overview on disease mechanisms, treatments, and research advances. Discov Med 10(52):213–224

    PubMed  Google Scholar 

  17. GBD 2017 Gastro-oesophageal Reflux Disease Collaborators (2020) The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global burden of disease study 2017. Lancet Gastroenterol Hepatol 5(6):561–581. https://doi.org/10.1016/S2468-1253(19)30408-X

    Article  Google Scholar 

  18. Wang R, Yan X, Ma XQ et al (2009) Burden of gastroesophageal reflux disease in Shanghai, China. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver 41(2):110–115. https://doi.org/10.1016/j.dld.2008.06.014

    Article  CAS  Google Scholar 

  19. Xiao S, Li J, Zheng H et al (2020) An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China. Eur Arch Otorhinolaryngol 277(10):2829–2838. https://doi.org/10.1007/s00405-020-06045-0

    Article  PubMed  Google Scholar 

  20. Madan K, Ahuja V, Gupta SD et al (2005) Impact of 24-h esophageal pH monitoring on the diagnosis of gastroesophageal reflux disease: defining the gold standard. J Gastroenterol Hepatol 20(1):30–37. https://doi.org/10.1111/j.1440-1746.2004.03530.x

    Article  PubMed  Google Scholar 

  21. Ming-Wun W, Ming-Jong B, Wei-Chuan C et al (2019) Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms. J Gastroenterol Hepatol 34(10):1720–1726. https://doi.org/10.1111/jgh.14651

    Article  Google Scholar 

  22. Ryan B, Karl-Hermann F, Wolfram B et al (2020) Clinical presentation of gastroesophageal reflux disease: a prospective study on symptom diversity and modification of questionnaire application. Dig Dis (Basel, Switzerland) 38(3):188–195. https://doi.org/10.1159/000502796

    Article  Google Scholar 

  23. Lechien Jerome R, Stéphane H, De Marrez LG et al (2021) Prevalence and features of laryngopharyngeal reflux in patients with primary burning mouth syndrome. Laryngoscope. https://doi.org/10.1002/lary.29604

    Article  PubMed  PubMed Central  Google Scholar 

  24. Rubin G, Uebel P, A. BRIMO-HAYEK, et al (2008) Validation of a brief symptom questionnaire (ReQuest in practice) for patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 27(9):846–851. https://doi.org/10.1111/j.1365-2036.2008.03641.x

    Article  CAS  PubMed  Google Scholar 

  25. Li YM, Du J, Zhang H et al (2008) Epidemiological investigation in outpatients with symptomatic gastroesophageal reflux from the Department of medicine in Zhejiang Province, east China. J Gastroenterol Hepatol 23(2):283–289. https://doi.org/10.1111/j.1440-1746.2007.05045.x

    Article  PubMed  Google Scholar 

  26. Richter JE, Rubenstein JH (2018) Presentation and epidemiology of gastroesophageal reflux disease. Gastroenterology 154(2):267–276. https://doi.org/10.1053/j.gastro.2017.07.045

    Article  PubMed  Google Scholar 

  27. Wong BC, Kinoshita Y (2006) Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc 4(4):398–407. https://doi.org/10.1016/j.cgh.2005.10.011

    Article  Google Scholar 

  28. Ivan K, Matthias P, Gerd J et al (2019) Modern esophageal function testing and gastroesophageal reflux disease in morbidly obese patients. Obes Surg 29(11):3536–3541. https://doi.org/10.1007/s11695-019-04020-1

    Article  Google Scholar 

  29. Nessjensen E, Hveem K, Elserag H et al (2016) Lifestyle intervention in gastroesophageal reflux disease. Clin Gastroenterol Hepatol Off Clin Prac J Am Gastroenterol Assoc 14(2):175–82.e823. https://doi.org/10.1016/j.cgh.2015.04.176

    Article  Google Scholar 

  30. Nessjensen E, Lindam A, Lagergren J et al (2013) Weight loss and reduction in gastroesophageal reflux. A prospective population-based cohort study: the HUNT study. Am J Gastroenterol 108(3):376–382. https://doi.org/10.1038/ajg.2012.466

    Article  Google Scholar 

  31. Hallan A, Bomme M, Hveem K, Møller-Hansen J, Ness-Jensen E (2015) Risk factors on the development of new-onset gastroesophageal reflux symptoms. A population-based prospective cohort study: the HUNT study. Am J Gastroenterol 110(3):393–401. https://doi.org/10.1038/ajg.2015.18

    Article  PubMed  Google Scholar 

  32. Wang JH, Luo JY, Dong L et al (2004) Epidemiology of gastroesophageal reflux disease: a general population-based study in Xi’an of Northwest China. World J Gastroenterol 10(11):1647–1651. https://doi.org/10.3748/wjg.v10.i11.1647

    Article  PubMed  PubMed Central  Google Scholar 

  33. Bujanda L (2000) The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol 95(12):3374–3382. https://doi.org/10.1111/j.1572-0241.2000.03347.x

    Article  CAS  PubMed  Google Scholar 

  34. Orr WC (2005) Night-time gastro-oesophageal reflux disease: prevalence, hazards, and management. Eur J Gastroenterol Hepatol 17(1):113–120. https://doi.org/10.1097/00042737-200501000-00021

    Article  PubMed  Google Scholar 

  35. Sandhu DS, Fass R (2018) Current trends in the management of gastroesophageal reflux disease. Gut Liver 12(1):7–16. https://doi.org/10.5009/gnl16615

    Article  CAS  PubMed  Google Scholar 

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Funding

This work was supported by Projects and Transformation Platform Construction Project of Guangdong Provincial ((2018) 1254 ⁃ 19) and High level university construction project of Guangzhou Medical University (B185004097).

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Authors and Affiliations

  1. State Key Laboratory of Respiratory Disease, Department of Otolaryngology–Head and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China

    Gui Chen, Weixing Liu, Wenjing Liao, Lijuan Song, Pingchang Yang & Xiaowen Zhang

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  1. Gui Chen
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Correspondence to Xiaowen Zhang.

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Chen, G., Liu, W., Liao, W. et al. An epidemiological survey of gastroesophageal reflux disease at the digestive endoscopy center in Guangzhou. Eur Arch Otorhinolaryngol 278, 4901–4908 (2021). https://doi.org/10.1007/s00405-021-06999-9

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