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The role of thymic stromal lymphopoietin in the development of chronic otitis media with effusion

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the effect of thymic stromal lymphopoietin on the development of chronic otitis media with effusion

Materials and methods

This study was conducted on 40 patients who had adenoidectomy operation. The objects were divided into two groups. Group 1; adenoidectomy with chronic serous otitis media, group 2; adenoidectomy without chronic serous otitis media. Serum and tissue thymic stromal lymphopoietin levels were measured by ELISA. Serum and tissue TLSP levels, mast cell count, adenoid size were compared between the groups.

Results

Twenty-four (60%) of patients were female and 16 (40%) were male. Twenty patients (55%) had adenoid hypertrophy with chronic serous otitis media, and 18 (45%) had adenoid hypertrophy without chronic serous otitis media. The mean age of the patients was 6.21 ± 2.31 years. The mean mast cell count was significantly higher in group 1 compared with group 2 (p = 0.017). The mean tissue thymic stromal lymphopoietin measurement was also significantly higher in group 1 than group 2 (p = 0.023). However, there was no significant difference in regards to serum levels between the groups (p = 0.480).

Conclusion

The number of mast cells as well as thymic stromal lymphopoietin levels in the adenoids of children was significantly high in the chronic serous otitis media patients. The release of thymic stromal lymphopoietin from the adenoid tissue plays a role in initiating and maintaining a local inflammatory reaction in the eustachian tube that may lead eventually to middle ear effusion in non-atopic patients.

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Funding

None. The authors did not receive support from any organization for the submitted work.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Darülaceze Cad. No: 25 Okmeydanı—Şişli, postal code: 34400, Istanbul, Turkey

    Tolgar Lütfi Kumral, Semih Karaketir & Hüseyin Sarı

  2. Department of Biochemistry, Okmeydanı Training and Research Hospital, Istanbul, Turkey

    Okan Dikker

  3. Department of Otorhinolaryngology-Head and Neck Surgery, Giresun University Medical Faculty, Giresun, Turkey

    Güven Yıldırım

  4. Department of Otorhinolaryngology-Head and Neck Surgery, Istinye Hospital, Istanbul, Turkey

    Cem Altındağ

  5. Department of Medical Biology, Cerrahpaşa University Medical Faculty, İstanbul, Turkey

    Mehmet Can Çakın

  6. Department of Pathology, Okmeydanı Training and Research Hospital, İstanbul, Turkey

    Deniz Özcan

Authors
  1. Tolgar Lütfi Kumral
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  2. Okan Dikker
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  3. Güven Yıldırım
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  4. Semih Karaketir
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  5. Cem Altındağ
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  6. Mehmet Can Çakın
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  7. Hüseyin Sarı
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  8. Deniz Özcan
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Contributions

All authors contributed to the study conception and design. Conceptualization: TLK, methodology: OD, MCÇ; formal analysis and investigation: SK, CA; writing—original draft preparation: TLK, HS; supervision: DÖ.

Corresponding author

Correspondence to Tolgar Lütfi Kumral.

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The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

Study was approved by the appropriate institutional research ethics committee.

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Kumral, T.L., Dikker, O., Yıldırım, G. et al. The role of thymic stromal lymphopoietin in the development of chronic otitis media with effusion. Eur Arch Otorhinolaryngol 279, 1937–1942 (2022). https://doi.org/10.1007/s00405-021-06995-z

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  • DOI: https://doi.org/10.1007/s00405-021-06995-z

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