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Effect of cisplatin chemotherapy on the inner ear function and serum prestin concentration

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

One of the main side effects of chemotherapy with cisplatin is irreversible sensorineural hearing loss. This study was conducted to assess the correlation between the serum prestin concentration as a potential cochlear biomarker and audiologic findings in patients after cisplatin chemotherapy.

Methods

A total of 52 patients aged 18–75 years were included in this prospective study. All the subjects were recruited from the radiotherapy and oncology center of a tertiary hospital in Rasht, Iran. Audiologic parameters evaluations and serum prestin concentrations were measured at baseline and after 1–3 weeks of chemotherapy. The inner ear function was evaluated by pure-tone audiometry (PTA) and distortion product of otoacoustic emission (DPOAE). A repeated-measure analysis of variance was performed to evaluate the relationship between the PTA, DPOAE, serum prestin concentration and cumulative cisplatin dose.

Results

Fifty-two patients (36 females) participated in this study. The PTA results showed that ototoxicity was more frequent among the patients with a high cumulative dose of cisplatin (χ2 trend = 15.25; P < 0.001). DPOAE responses revealed that 38.5% of the patients had ototoxicity change after 40–80 mg of cisplatin administration. After receiving 40–80 mg of cisplatin, serum prestin concentration increased from 130 to 230 pg/ml. There is a significant positive correlation between prestin concentration after receiving more than 80 mg of cisplatin and the ototoxic changes in the DPOAE response.

Conclusion

The present study showed correlations between prestin concentrations and ototoxicity diagnosis by DPOAE findings. An early rise in prestin concentration is particularly important and an early sign of hearing loss. Future studies are recommended to investigate the effect of varying doses of cisplatin on prestin concentration and any association between ototoxicity and clinicopathological features.

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Original data are available.

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Funding

This study was supported by a Grant (97051304) of the Guilan University of Medical Sciences (GUMS), Iran.

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Authors and Affiliations

  1. Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

    Mir Mohammad Jalali

  2. GI Cancer Screening and Prevention Research Center, Department of Radiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

    Hamid Saeidi Saedi

  3. Medical Education Research Center, Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

    Farshid Saadat

Authors
  1. Mir Mohammad Jalali
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  3. Farshid Saadat
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Contributions

MMJ, HS and FS conceived the study. MMJ and HS collected the data. MMJ analyzed and interpreted the data. FS and MMJ drafted the manuscript. MMJ, HS and FS revised and approved the final manuscript.

Corresponding author

Correspondence to Mir Mohammad Jalali.

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The authors declare no conflict of interest.

Ethics approval

The study protocol was approved by the local Ethics Committees in accordance with the Helsinki declaration (IR.GUMS.REC.1397.202).

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Written informed consent was obtained.

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Jalali, M.M., Saedi, H.S. & Saadat, F. Effect of cisplatin chemotherapy on the inner ear function and serum prestin concentration. Eur Arch Otorhinolaryngol 279, 2783–2789 (2022). https://doi.org/10.1007/s00405-021-06967-3

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  • DOI: https://doi.org/10.1007/s00405-021-06967-3

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