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Effectiveness of intranasal steroids on rhinitis symptoms, sleep quality, and quality of life in patients with perennial allergic rhinitis

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Evaluate the impact of perennial allergic rhinitis (PAR) on the health-related quality of life (HRQL) and measure performance issues that are of major concerns for PAR patients, as well as determining the effect of intra-nasal steroids (INS) on PAR and associated congestion, sleep complaints, and daytime sleepiness.

Methods

This study was a cross-sectional study. A total of 78 PAR patients underwent otorhinolaryngological examination and skin test. All participants filled in the Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ), the Stanford Sleepiness Scale (SSS), and the Epworth Sleepiness Scale (ESS). Participants were asked to undergo treatment with Budesonide (BUD) topical aqueous nasal spray for eight weeks. After the treatment period, all participants were again asked to answer the three questionnaires.

Results

The results of this study found statistically significant improvements in the overall NRQLQ score (p < 0.001) and individual NRQLQ domain scores (p < 0.05) after INS treatment.

A statistically significant reduction in symptom severity in the four NRQLQ domains before and after treatment was found (p < 0.05), except for restlessness, post-nasal drip, and avoiding symptom triggers (p = 0.575, 0.172, and 0.705, respectively). There was a statistically significant difference in ESS and SSS scores before and after treatment (p < 0.001).

Conclusion

PAR has a significant impact on sleep quality and, as a result, a lower QOL. This study demonstrates that INS is an effective modality in the treatment of PAR and positively impacts patients' QOL by improving nasal symptoms, daytime fatigue, and somnolence, and sleep quality.

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Availability of data and material

The author confirms that the data supporting the findings of this study are available within the article.

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Acknowledgment

The author thanks all the patients who took part in this work for their help.

Funding

The author has no funding or financial relationships to disclose.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt

    Marwa Abdelhafeez

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  1. Marwa Abdelhafeez
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Correspondence to Marwa Abdelhafeez.

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All ethical considerations were completed before the study. Ethical approval from the Medical University Research Center has been requested (IRB No. 20–0552).

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Informed consent was obtained prior to the start of the study. Thus, the participants were informed about the objectives of the study and the steps in carrying it out, as well as about its risks and benefits.

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Abdelhafeez, M. Effectiveness of intranasal steroids on rhinitis symptoms, sleep quality, and quality of life in patients with perennial allergic rhinitis. Eur Arch Otorhinolaryngol 279, 249–256 (2022). https://doi.org/10.1007/s00405-021-06818-1

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  • DOI: https://doi.org/10.1007/s00405-021-06818-1

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