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A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma

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Abstract

Background

The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients.

Materials and methods

Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes.

Results

Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P < 0.05). A nomogram was constructed with a c-index of 0.702.

Conclusion

A novel clinical signature including hemoglobin level, BMI, and NLR, which are obtained through noninvasive examinations can be used as prognostic indicators in clinical practice for elderly patients with OSCC.

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Funding

This study was supported by Grants from the National Natural Science Foundation of China (81972589 and 81672745) and Program of Innovative Research Team of High-level Local Universities in Shanghai.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial and Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Wenkai Zhou, Zheqi Liu & Wei Cao

  2. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, 200011, People’s Republic of China

    Wenkai Zhou, Zheqi Liu & Wei Cao

  3. School and Hospital of Stomatology, Kunming Medical University, Kunming, China

    Canbang Peng

Authors
  1. Wenkai Zhou
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  2. Canbang Peng
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  3. Zheqi Liu
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  4. Wei Cao
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Contributions

WC, ZL conceived the project and designed the research. CP and ZL did the follow-up work. ZL carried out the data analyzing. WZ interpreted the data and made the figures and wrote the manuscript. The study supervisors are WC. All authors read and approved the final manuscript.

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Correspondence to Zheqi Liu or Wei Cao.

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Zhou, W., Peng, C., Liu, Z. et al. A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma. Eur Arch Otorhinolaryngol 279, 391–398 (2022). https://doi.org/10.1007/s00405-021-06786-6

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  • DOI: https://doi.org/10.1007/s00405-021-06786-6

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