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The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

The etiology of allergic rhinitis (AR) is closely correlated with the complex interactions between genetic and environmental factors. This study explored the effect of single-nucleotide polymorphisms (SNPs) of CYSLTR1 gene on the risk of AR and clinical response to montelukast treatment in children.

Methods

A total of 135 children with AR and 100 healthy children were included for subsequent analyses. Genotype and allele distribution of rs321029 SNP of CYSLTR1 gene and inflammatory mediators were detected and compared between AR and healthy children.

Results

Genotype and allele frequency of rs321029 SNP of CYSLTR1 gene showed no difference between children with AR and controls or between AR cases with different severity. The total montelukast effective rate of wide-type genotype TT children was significantly higher than variants genotype CC children.

Conclusion

Polymorphism of rs321029 on CYSLTR1 gene is not related to the susceptibility and severity of AR in children, but it is closely related with the efficacy of montelukast on AR.

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Authors and Affiliations

  1. Taishan Vocational College of Nursing, Taian, Shandong Province, China

    Miaomiao Zhao

  2. Department of Bloodlood Transfusion, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong Province, China

    Hao Li

  3. Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong Province, China

    Hui Li

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  1. Miaomiao Zhao
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All authors contributed significantly to the work, have seen and approved the manuscript.

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Correspondence to Hao Li or Hui Li.

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The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Shandong Provincial Hospital Affiliated to Shandong First Medical University.

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Informed consent was obtained from all the children' parents for both participation and publication of the study.

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Zhao, M., Li, H. & Li, H. The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children. Eur Arch Otorhinolaryngol 278, 4847–4853 (2021). https://doi.org/10.1007/s00405-021-06771-z

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  • DOI: https://doi.org/10.1007/s00405-021-06771-z

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