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Survival outcomes of patients with subglottic squamous cell carcinoma : a study of the National Cancer Database

  • Head and Neck
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Abstract

Background

Subglottic squamous cell carcinoma (SCC) represents less than 5% of all laryngeal cancers. Our objective was to better characterize survival using the National Cancer Database (NCDB) registry from 2004 to 2015.

Results

403 patients met inclusion criteria. 63.8% presented with advanced-stage disease. Treatment regimens were as follows: 15.9% underwent surgery alone, 16.9% underwent surgery followed by adjuvant therapy, and 67.2% underwent primary chemo/radiation (C/RT). Five-year overall survival (OS) was 58.6% for Stage I and II patients, 49.1% for Stage III, and 36.3% for stage IV. Adjusted OS for all-stage patients was worse with C/RT compared to upfront surgery (40.6% vs. 58.4%; HR 1.83 [95%CI 1.29–2.61] p < 0.001) and adjusted OS for stage 4 disease was significantly worse with C/RT compared to surgery (26.0% vs. 45.2%, HR 1.79 [95%CI 1.17–2.73] p = 0.007).

Conclusion

Majority of patients were treated with primary C/RT. Adjusted survival favors upfront surgery versus C/RT, especially in patients with Stage IV disease.

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Authors and Affiliations

  1. Department of Otolaryngology–Head and Neck Surgery, The Ohio State University, Columbus, OH, USA

    Lucy L. Shi

  2. Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Caitlin McMullen, Kathryn Vorwald, J. Trad Wadsworth, Christine H. Chung & Krupal B. Patel

  3. Department of Otolaryngology–Head and Neck Surgery, Western University, London, ON, Canada

    Anthony C. Nichols & S. Danielle MacNeil

  4. Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Xuefeng Wang

Authors
  1. Lucy L. Shi
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  2. Caitlin McMullen
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  3. Kathryn Vorwald
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  4. Anthony C. Nichols
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  5. S. Danielle MacNeil
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  6. J. Trad Wadsworth
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  7. Christine H. Chung
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  8. Xuefeng Wang
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  9. Krupal B. Patel
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Contributions

The NCDB is a joint project of the Commission on Cancer of the American College of Surgeons and the American Cancer Society. The data used in the study are derived from a de-identified NCDB file. The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic or statistical methodology employed, or the conclusions drawn from these data by the investigator.

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Correspondence to Krupal B. Patel.

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Shi, L.L., McMullen, C., Vorwald, K. et al. Survival outcomes of patients with subglottic squamous cell carcinoma : a study of the National Cancer Database. Eur Arch Otorhinolaryngol 278, 4923–4932 (2021). https://doi.org/10.1007/s00405-021-06712-w

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  • DOI: https://doi.org/10.1007/s00405-021-06712-w

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