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Can the sensitisation to staphylococcal enterotoxin predict the severity of chronic rhinosinusitis?

  • Rhinology
  • Published:
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Abstract

Background

Evidence is accumulating that Staphylococcus aureus plays an important role as a disease modifier in upper and lower airway disease. We aimed to assess the association of staphylococcal enterotoxins (SEs) with allergic multimorbidity as well as the severity of chronic rhinosinusitis.

Methods

We retrospectively reviewed the medical records of 97 subjects aged 6 years or older between March 2018 and June 2019 and analysed symptom scores, computed tomography scores, serum IgE levels to SEs, serum total and specific IgE levels to inhalant allergens. To evaluate eosinophilic chronic rhinosinusitis (ECRS), we used refractory ECRS score from the Japanese epidemiological survey.

Results

Of the 97 patients enrolled, 29 (29.9%) were non-sensitised, 33 (34.0%) were mono-sensitised, and 35 (36.1%) were poly-sensitised. Sensitisation to SEs was closely associated with poly-sensitisation to inhalant allergens. SE-sensitised participants had higher median values for total and specific IgE levels to inhalant allergens than did non-SE-sensitised participants. SE sensitisation was associated with allergic multimorbidity and severe allergic diseases, such as ECRS.

Conclusions

This preliminary study suggested that sensitisation to SEs may play a role in the initiation of type-2 inflammatory responses, such as allergic rhinitis, ECRS, and allergic multimorbidity. Furthermore, sensitisation to SEs correlated with the severity of ECRS.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Ilsan-ro 20, Wonju, South Korea

    Eun Jung Lee & Dong-Joon Park

  2. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea

    Chang-Hoon Kim, Joo-Heon Yoon & Hyung-Ju Cho

  3. The Airway Mucus Institute, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea

    Chang-Hoon Kim, Joo-Heon Yoon & Hyung-Ju Cho

  4. Korea Mouse Phenotyping Center, Yonsei University College of Medicine, Seoul, South Korea

    Chang-Hoon Kim, Joo-Heon Yoon & Hyung-Ju Cho

  5. Yonsei Sol Clinic of Otorhinolaryngology, Seoul, South Korea

    Chi Sang Hwang

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  1. Eun Jung Lee
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Correspondence to Eun Jung Lee.

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The authors decalre that they have no competing interest.

Research involving human participants and/or animals

This study was approved by the Institutional Review Board of Yonsei University Wonju College of Medicine (No. CR319068) in accordance with the Declaration of Helsinki.

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The participants provided written informed consent at baseline.

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Lee, E.J., Kim, CH., Yoon, JH. et al. Can the sensitisation to staphylococcal enterotoxin predict the severity of chronic rhinosinusitis?. Eur Arch Otorhinolaryngol 278, 2829–2836 (2021). https://doi.org/10.1007/s00405-020-06526-2

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  • DOI: https://doi.org/10.1007/s00405-020-06526-2

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