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Changes in olfactory function and olfactory bulb after treatment for acromegaly

  • Rhinology
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This study aimed to investigate the olfactory functions of the acromegaly patients and to discuss the possible causes of olfactory dysfunction in acromegaly patients.


A case–control study was carried out in a tertiary referral center. 52 patients with acromegaly (Acromegaly group) and 52 healthy individuals (Control group) were included in the study. All acromegaly patients included in the study were in the late postoperative period. The Connecticut Chemosensory Clinical Research Center (CCCRC) test was carried out and olfactory bulb (OB) volumes were measured in both of the groups.


There was a significant difference between the mean CCCRC total scores of the acromegaly and control groups (p = .000). The mean of right and left OB volumes in the acromegaly group was significantly higher than the control group (p = .004)


In this study, we found that acromegaly patients are likely to experience olfactory dysfunction. It is important to examine these patients’ olfactory functions at the time of diagnosis and clinic follow-up.

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This study was supported by Bezmialem Vakif University Scientific Research Projects Unit.

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Authors and Affiliations



All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by HB, ES, MI, AG, EUMY and SBE. The first draft of the manuscript was written by ND and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Nazan Degirmenci.

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The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

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Informed consent was obtained from all individual participants included in the study.

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Degirmenci, N., Bektas, H., Senturk, E. et al. Changes in olfactory function and olfactory bulb after treatment for acromegaly. Eur Arch Otorhinolaryngol 278, 2357–2362 (2021).

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