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Temporal bone carcinoma: testing the prognostic value of a novel clinical and histological scoring system

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Our group recently proposed the novel Padova prognostic scoring system for temporal bone carcinoma (TBSCC) that considers: the revised Pittsburgh staging system; radiological dura mater involvement; non-anterior spread (medial, inferior or posterior into the temporal bone and skull base) of T4 tumors; and histological grade. The aim of the present study was to validate this prognostic TBSCC scoring system in a case series selected from the literature.

Methods

A search was run to identify studies on TBSCC reporting the variables included in our score for each patient. Then our system was applied to the data extracted.

Results

Only two published investigations reported all the clinical and pathological data required for our scoring system. In one series from the Gruppo Otologico in Piacenza (Italy), a significantly higher recurrence rate (p = 0.008), shorter disease-free survival (DFS) (p = 0.001), higher disease-specific mortality (DSM) (p = 0.006), and shorter disease-specific survival (DSS) (p = 0.004) were associated with scores ≥ 5. Receiver operating curve (ROC) analysis showed an AUC of 0.804 for TBSCC recurrence, and 0.832 for DSM. In a series from Kyushu University Hospital (Japan), a significantly higher DSM (p = 0.018) and shorter DSS (p = 0.021) were associated with scores ≥ 5. ROC analysis showed an AUC of 0.812 for tumor relapse and 0.790 for DSM.

Conclusion

Our TBSCC Padova scoring system confirmed its validity when applied to the only two international TBSCC series providing the required data. These preliminary results need to be confirmed in a multi-center prospective setting.

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Data availability

Employed data were retrieved from published articles available (see text for detail).

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Acknowledgements

The authors thank Frances Coburn for correcting the English version of this paper.

Funding

This study was partly supported by Grant no. DOR1951845/19 (G. Marioni) from the University of Padova, Italy.

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Author notes

  1. Leonardo Franz and Elisabetta Zanoletti contributed equally to the manuscript’s preparation.

Authors and Affiliations

  1. Department of Neuroscience DNS, Otolaryngology Section, Padova University, Via Giustiniani 2, 35128, Padova, Italy

    Leonardo Franz, Elisabetta Zanoletti, Sebastiano Franchella, Diego Cazzador, Niccolò Favaretto, Leonardo Calvanese, Antonio Mazzoni, Piero Nicolai & Gino Marioni

  2. Department of Women’s and Children’s Health, University of Padova, Padova, Italy

    Sebastiano Franchella

  3. Department of Neuroscience DNS, Section of Human Anatomy, Padova University, Padova, Italy

    Diego Cazzador

Authors
  1. Leonardo Franz
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  2. Elisabetta Zanoletti
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  3. Sebastiano Franchella
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  4. Diego Cazzador
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  6. Leonardo Calvanese
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  7. Antonio Mazzoni
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  8. Piero Nicolai
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  9. Gino Marioni
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Contributions

Conceptualization: LF, EZ, AM, and GM. Methodology: LF, GM. Formal analysis: LF. Investigation: LF, EZ, SF, DC, NF, LC, AM, PN and GM. Resources: GM. Data curation: LF, EZ, SF, NF, DC, LC, GM. Writing—original draft preparation: LF, EZ, SF, DC, NF, LC, AM, PN and GM. Writing—review and editing: LF, EZ, SF, DC, NF, LC, AM, PN, and GM. Visualization: LF, EZ, SF, DC, NF, LC, AM, PN and GM. Supervision: AM, GM and PN. Project administration: EZ, LF, AM, PN and GM. Funding acquisition: GM.

Corresponding author

Correspondence to Gino Marioni.

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Franz, L., Zanoletti, E., Franchella, S. et al. Temporal bone carcinoma: testing the prognostic value of a novel clinical and histological scoring system. Eur Arch Otorhinolaryngol 278, 4179–4186 (2021). https://doi.org/10.1007/s00405-020-06489-4

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  • DOI: https://doi.org/10.1007/s00405-020-06489-4

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