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Serum prolidase, malondialdehyde and catalase levels for the evaluation of oxidative stress in patients with peripheral vertigo

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels.

Methods

A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method.

Results

The most common cause of vertigo was BPPV (53.3%), followed by Ménière’s disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05).

Conclusion

We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.

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Funding

There are no specific financial interests, relationships, and affiliations relevant to the subject of the manuscript. These can include employment, consultancies, honoraria, stock ownership, etc.

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Authors and Affiliations

  1. Department of Otolaryngology, Atasehir Avicenna Hospital, Istanbul, Turkey

    Isa Ozbay

  2. Department of Otolaryngology, Kutahya Saglık Bilimleri University, Kutahya, Turkey

    Muhammet Fatih Topuz & Fatih Oghan

  3. Department of Biochemistry, Kutahya Saglık Bilimleri University, Kutahya, Turkey

    Havva Kocak

  4. Department of Otolaryngology, Bezmi Alem Vakıf University, Istanbul, Turkey

    Cuneyt Kucur

Authors
  1. Isa Ozbay
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  2. Muhammet Fatih Topuz
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  3. Fatih Oghan
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  4. Havva Kocak
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  5. Cuneyt Kucur
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Corresponding author

Correspondence to Fatih Oghan.

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Conflict of interest

There is no financial or personal relationship with other people or organizations that could inappropriately influence (bias) the authors’ actions.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants recruited in the study.

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Ozbay, I., Topuz, M.F., Oghan, F. et al. Serum prolidase, malondialdehyde and catalase levels for the evaluation of oxidative stress in patients with peripheral vertigo. Eur Arch Otorhinolaryngol 278, 3773–3776 (2021). https://doi.org/10.1007/s00405-020-06466-x

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  • DOI: https://doi.org/10.1007/s00405-020-06466-x

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